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• W2913664658 abstract "Apoptosis is an integral part of homeostasis and supports multiple physiological processes such as development and immune defense, thereby directly targeting damaged or unwanted cells without affecting neighbor cells. In the present study, we characterized the apoptotic key factors caspase-3, -7, and - 8 as well as regulator protein TPT1 (translationally-controlled tumor protein 1) from rainbow trout (Oncorhynchus mykiss). We identified multiple single-nucleotide changes in their coding sequences and showed that the CASP3 gene is present in at least three variants. Caspase genes were clustered to their orthologs in bony fish and human by using evolutionary analysis. Expression profiling in seven tissues of unchallenged adult fish revealed predominant transcript levels in the head kidney (CASP3, 7, and 8) or brain (TPT1). Further, we analyzed the expression of a more comprehensive panel of 16 trout genes encoding pro- and anti-apoptotic factors and associated proteins during development and upon stress exposure (in vitro temperature and staurosporine treatment). Previously published transcriptome data suggested that the induction of apoptotic processes is mirrored on the transcript level, but this could not be confirmed by the present gene-profiling study. Yet on the protein level, treatment of trout cell line RT-gill-W1 with 1 μM staurosporine for up to 120 min led to a significant increase of CASP3/7 activity. Moreover, a meta-analysis on published data showed that stress-related expression could only be detected sporadically for apoptotic key factors. In conclusion, there seems to be no reliable pattern or marker representing the stress-related induction of apoptosis in salmonids." @default.
• W2913664658 created "2019-02-21" @default.
• W2913664658 creator A5000775118 @default.
• W2913664658 creator A5022225462 @default.
• W2913664658 creator A5031535803 @default.
• W2913664658 creator A5052578186 @default.
• W2913664658 creator A5054425247 @default.
• W2913664658 creator A5072486823 @default.
• W2913664658 date "2019-04-01" @default.
• W2913664658 modified "2023-10-02" @default.
• W2913664658 title "A molecular survey of programmed cell death in rainbow trout: Structural and functional specifications of apoptotic key molecules" @default.
• W2913664658 cites W1526776209 @default.
• W2913664658 cites W1537274817 @default.
• W2913664658 cites W1590593712 @default.
• W2913664658 cites W1817123886 @default.
• W2913664658 cites W1965002009 @default.
• W2913664658 cites W1965729882 @default.
• W2913664658 cites W1968136345 @default.
• W2913664658 cites W1969554538 @default.
• W2913664658 cites W1969600436 @default.
• W2913664658 cites W1970373764 @default.
• W2913664658 cites W1971896762 @default.
• W2913664658 cites W1972586432 @default.
• W2913664658 cites W1974476065 @default.
• W2913664658 cites W1975365319 @default.
• W2913664658 cites W1976923037 @default.
• W2913664658 cites W1977656513 @default.
• W2913664658 cites W1977832502 @default.
• W2913664658 cites W1980001465 @default.
• W2913664658 cites W1993237163 @default.
• W2913664658 cites W1995401139 @default.
• W2913664658 cites W1996569348 @default.
• W2913664658 cites W1996593883 @default.
• W2913664658 cites W1997559051 @default.
• W2913664658 cites W2000528034 @default.
• W2913664658 cites W2003407962 @default.
• W2913664658 cites W2008757142 @default.
• W2913664658 cites W2009601373 @default.
• W2913664658 cites W2010372867 @default.
• W2913664658 cites W2013454338 @default.
• W2913664658 cites W2015892611 @default.
• W2913664658 cites W2020395672 @default.
• W2913664658 cites W2021113636 @default.
• W2913664658 cites W2021829013 @default.
• W2913664658 cites W2022980475 @default.
• W2913664658 cites W2024105041 @default.
• W2913664658 cites W2025267218 @default.
• W2913664658 cites W2027783756 @default.
• W2913664658 cites W2028001397 @default.
• W2913664658 cites W2030650665 @default.
• W2913664658 cites W2031184524 @default.
• W2913664658 cites W2034071655 @default.
• W2913664658 cites W2034499270 @default.
• W2913664658 cites W2038672793 @default.
• W2913664658 cites W2039355845 @default.
• W2913664658 cites W2040401741 @default.
• W2913664658 cites W2042087846 @default.
• W2913664658 cites W2045585885 @default.
• W2913664658 cites W2046533001 @default.
• W2913664658 cites W2047750593 @default.
• W2913664658 cites W2049097459 @default.
• W2913664658 cites W2050830063 @default.
• W2913664658 cites W2052853635 @default.
• W2913664658 cites W2052994390 @default.
• W2913664658 cites W2056155809 @default.
• W2913664658 cites W2059738518 @default.
• W2913664658 cites W2060200357 @default.
• W2913664658 cites W2060259273 @default.
• W2913664658 cites W2060410266 @default.
• W2913664658 cites W2060672363 @default.
• W2913664658 cites W2061068411 @default.
• W2913664658 cites W2065371606 @default.
• W2913664658 cites W2066540709 @default.
• W2913664658 cites W2066715837 @default.
• W2913664658 cites W2068084708 @default.
• W2913664658 cites W2071649344 @default.
• W2913664658 cites W2080093693 @default.
• W2913664658 cites W2082624222 @default.
• W2913664658 cites W2084517753 @default.
• W2913664658 cites W2085381267 @default.
• W2913664658 cites W2086391359 @default.
• W2913664658 cites W2091068801 @default.
• W2913664658 cites W2091472261 @default.
• W2913664658 cites W2097241637 @default.
• W2913664658 cites W2099081932 @default.
• W2913664658 cites W2099484456 @default.
• W2913664658 cites W2102766596 @default.
• W2913664658 cites W2108935540 @default.
• W2913664658 cites W2116029362 @default.
• W2913664658 cites W2122935205 @default.
• W2913664658 cites W2125544838 @default.
• W2913664658 cites W2127205046 @default.
• W2913664658 cites W2127206230 @default.
• W2913664658 cites W2132471728 @default.
• W2913664658 cites W2141376519 @default.
• W2913664658 cites W2142911981 @default.
• W2913664658 cites W2168313721 @default.
• W2913664658 cites W2168596078 @default.

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