Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913671047> ?p ?o ?g. }
- W2913671047 abstract "Effective vaccines inducing lifelong protection against many important infections such as respiratory syncytial virus (RSV), human immunodeficiency virus (HIV), influenza and Epstein-Barr virus (EBV) are not yet available despite decades of research. As an alternative to a protective vaccine we developed a genetic engineering strategy in which CRISPR/Cas9 was utilized to replace endogenously-encoded antibodies with antibodies protective against RSV, HIV, influenza or EBV in primary human or murine B cells. The engineered antibodies were expressed in up to 59% of primary B cells under the control of endogenous regulatory elements, which maintained normal antibody expression and secretion. Importantly, a single transfer of murine B cells engineered to express an antibody protective against RSV resulted in potent and durable protection against RSV infection in immunocompromised hosts. This approach offers the opportunity to achieve sterilizing immunity against pathogens for which traditional vaccination has failed to induce or maintain protective antibody responses." @default.
- W2913671047 created "2019-02-21" @default.
- W2913671047 creator A5015544350 @default.
- W2913671047 creator A5030465955 @default.
- W2913671047 creator A5057074581 @default.
- W2913671047 creator A5065632813 @default.
- W2913671047 creator A5075253163 @default.
- W2913671047 creator A5079233061 @default.
- W2913671047 date "2019-02-06" @default.
- W2913671047 modified "2023-10-04" @default.
- W2913671047 title "B cells engineered to express pathogen-specific antibodies using CRISPR/Cas9 protect against infection" @default.
- W2913671047 cites W1191516621 @default.
- W2913671047 cites W1541751114 @default.
- W2913671047 cites W1816587284 @default.
- W2913671047 cites W1969913120 @default.
- W2913671047 cites W1980965429 @default.
- W2913671047 cites W1989501142 @default.
- W2913671047 cites W1990559406 @default.
- W2913671047 cites W1992566288 @default.
- W2913671047 cites W2008073080 @default.
- W2913671047 cites W2019706667 @default.
- W2913671047 cites W2030522563 @default.
- W2913671047 cites W2052274930 @default.
- W2913671047 cites W2057893650 @default.
- W2913671047 cites W2062215675 @default.
- W2913671047 cites W2067779211 @default.
- W2913671047 cites W2071273914 @default.
- W2913671047 cites W2076198413 @default.
- W2913671047 cites W2122732537 @default.
- W2913671047 cites W2123817481 @default.
- W2913671047 cites W2123976877 @default.
- W2913671047 cites W2124528183 @default.
- W2913671047 cites W2126114330 @default.
- W2913671047 cites W2128152661 @default.
- W2913671047 cites W2135151522 @default.
- W2913671047 cites W2141699640 @default.
- W2913671047 cites W2170755007 @default.
- W2913671047 cites W2319448932 @default.
- W2913671047 cites W2320044375 @default.
- W2913671047 cites W2491163602 @default.
- W2913671047 cites W2531690106 @default.
- W2913671047 cites W2615390960 @default.
- W2913671047 cites W2619886251 @default.
- W2913671047 cites W2727509207 @default.
- W2913671047 cites W2758496793 @default.
- W2913671047 cites W2759402071 @default.
- W2913671047 cites W2759860792 @default.
- W2913671047 cites W2770505353 @default.
- W2913671047 cites W2774294088 @default.
- W2913671047 cites W2786695043 @default.
- W2913671047 cites W2802763804 @default.
- W2913671047 cites W2808415597 @default.
- W2913671047 cites W2883871745 @default.
- W2913671047 cites W2894307280 @default.
- W2913671047 cites W2898192919 @default.
- W2913671047 cites W2950101654 @default.
- W2913671047 doi "https://doi.org/10.1101/541979" @default.
- W2913671047 hasPublicationYear "2019" @default.
- W2913671047 type Work @default.
- W2913671047 sameAs 2913671047 @default.
- W2913671047 citedByCount "2" @default.
- W2913671047 countsByYear W29136710472021 @default.
- W2913671047 countsByYear W29136710472022 @default.
- W2913671047 crossrefType "posted-content" @default.
- W2913671047 hasAuthorship W2913671047A5015544350 @default.
- W2913671047 hasAuthorship W2913671047A5030465955 @default.
- W2913671047 hasAuthorship W2913671047A5057074581 @default.
- W2913671047 hasAuthorship W2913671047A5065632813 @default.
- W2913671047 hasAuthorship W2913671047A5075253163 @default.
- W2913671047 hasAuthorship W2913671047A5079233061 @default.
- W2913671047 hasBestOaLocation W29136710471 @default.
- W2913671047 hasConcept C104317684 @default.
- W2913671047 hasConcept C159047783 @default.
- W2913671047 hasConcept C159654299 @default.
- W2913671047 hasConcept C203014093 @default.
- W2913671047 hasConcept C22070199 @default.
- W2913671047 hasConcept C2522874641 @default.
- W2913671047 hasConcept C2776460866 @default.
- W2913671047 hasConcept C54355233 @default.
- W2913671047 hasConcept C86803240 @default.
- W2913671047 hasConcept C98108389 @default.
- W2913671047 hasConceptScore W2913671047C104317684 @default.
- W2913671047 hasConceptScore W2913671047C159047783 @default.
- W2913671047 hasConceptScore W2913671047C159654299 @default.
- W2913671047 hasConceptScore W2913671047C203014093 @default.
- W2913671047 hasConceptScore W2913671047C22070199 @default.
- W2913671047 hasConceptScore W2913671047C2522874641 @default.
- W2913671047 hasConceptScore W2913671047C2776460866 @default.
- W2913671047 hasConceptScore W2913671047C54355233 @default.
- W2913671047 hasConceptScore W2913671047C86803240 @default.
- W2913671047 hasConceptScore W2913671047C98108389 @default.
- W2913671047 hasLocation W29136710471 @default.
- W2913671047 hasOpenAccess W2913671047 @default.
- W2913671047 hasPrimaryLocation W29136710471 @default.
- W2913671047 hasRelatedWork W124972543 @default.
- W2913671047 hasRelatedWork W1487857142 @default.
- W2913671047 hasRelatedWork W1547625320 @default.
- W2913671047 hasRelatedWork W1561127041 @default.
- W2913671047 hasRelatedWork W2062279822 @default.
- W2913671047 hasRelatedWork W2099932062 @default.