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- W2913693532 abstract "The physical remodeling associated with cancer progression results in barriers to mass transport in the tumor interstitial space. This hindrance ultimately affects the distribution of macromolecules that govern cell fate and potency of cancer therapies. Therefore, knowing how specific extracellular matrix (ECM) and cellular components regulate transport in the tumor interstitium could lead to matrix normalizing strategies that improve patient outcome. Studies over the past decades have provided quantitative insights into interstitial transport in tumors by characterizing two governing parameters: (1) molecular diffusivity and (2) hydraulic conductivity. However, many of the conventional techniques used to measure these parameters are limited due to their inability to experimentally manipulate the physical and cellular environments of tumors. Here, we examine the application and future opportunities of microfluidic systems for identifying the physiochemical mediators of mass transport in the tumor ECM. Further advancement and adoption of microfluidic systems to quantify tumor transport parameters has potential to bridge basic science with translational research for advancing personalized medicine in oncology." @default.
- W2913693532 created "2019-02-21" @default.
- W2913693532 creator A5001800512 @default.
- W2913693532 creator A5054684833 @default.
- W2913693532 creator A5086584544 @default.
- W2913693532 date "2019-01-23" @default.
- W2913693532 modified "2023-10-12" @default.
- W2913693532 title "Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix" @default.
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- W2913693532 doi "https://doi.org/10.3389/fbioe.2019.00006" @default.
- W2913693532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6364047" @default.
- W2913693532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30761297" @default.
- W2913693532 hasPublicationYear "2019" @default.
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