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• W2913693754 startingPage "36" @default.
• W2913693754 abstract "Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with two major behavioral symptoms i.e. repetitive behavior and social-communication impairment. The unknown etiology of ASD is responsible for the difficulty in identifying the possible therapeutic modulators for ASD. Valproic acid (VPA) is an anticonvulsant drug in both human and rodents with teratogenic effects during pregnancy. Therefore, prenatal exposure of VPA induced autism spectrum disorder like phenotypes in both human and rodents. Peroxisome proliferator-activated receptor-alpha (PPAR-α) is widely localized in the brain. This research investigates the utility of fenofibrate, a selective agonist of PPAR-α in prenatal VPA-induced experimental ASD in Wistar rats. The prenatal VPA has induced social impairment (three chambers social behavior apparatus), repetitive behavior (Y-maze), hyperlocomotion (actophotometer), anxiety (elevated plus maze) and low exploratory activity (hole board test). Also, prenatal VPA treated rats have shown higher levels of oxidative stress (increased in thiobarbituric acid reactive species and decreased in reduced glutathione level) and inflammation (increased in interleukin-6, tumor necrosis factor-α and decreased in interleukin-10) in the cerebellum, brainstem and prefrontal cortex. Treatment with fenofibrate significantly attenuated prenatal VPA-induced social impairment, repetitive behavior, hyperactivity, anxiety, and low exploratory activity. Furthermore, fenofibrate also decreased the prenatal VPA-induced oxidative stress and inflammation in brain regions. Hence, it may be concluded that fenofibrate may provide neurobehavioral and biochemical benefits in prenatal VPA-induced autism phenotypes in rats." @default.
• W2913693754 created "2019-02-21" @default.
• W2913693754 creator A5027888114 @default.
• W2913693754 creator A5043328456 @default.
• W2913693754 date "2019-04-01" @default.
• W2913693754 modified "2023-10-02" @default.
• W2913693754 title "Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats" @default.
• W2913693754 cites W1569350967 @default.
• W2913693754 cites W1775749144 @default.
• W2913693754 cites W1779532143 @default.
• W2913693754 cites W1926095516 @default.
• W2913693754 cites W1948818227 @default.
• W2913693754 cites W1970834718 @default.
• W2913693754 cites W1973523291 @default.
• W2913693754 cites W1978172411 @default.
• W2913693754 cites W1979655796 @default.
• W2913693754 cites W1983310681 @default.
• W2913693754 cites W1983889199 @default.
• W2913693754 cites W1986696152 @default.
• W2913693754 cites W1992679116 @default.
• W2913693754 cites W2001768156 @default.
• W2913693754 cites W2010568688 @default.
• W2913693754 cites W2018749573 @default.
• W2913693754 cites W2026261879 @default.
• W2913693754 cites W2028878165 @default.
• W2913693754 cites W2031140625 @default.
• W2913693754 cites W2034035188 @default.
• W2913693754 cites W2035570187 @default.
• W2913693754 cites W2037553020 @default.
• W2913693754 cites W2037971926 @default.
• W2913693754 cites W2040305564 @default.
• W2913693754 cites W2043365657 @default.
• W2913693754 cites W2044796707 @default.
• W2913693754 cites W2053844486 @default.
• W2913693754 cites W2053909439 @default.
• W2913693754 cites W2054445906 @default.
• W2913693754 cites W2062412105 @default.
• W2913693754 cites W2063342955 @default.
• W2913693754 cites W2066597177 @default.
• W2913693754 cites W2073317062 @default.
• W2913693754 cites W2073874214 @default.
• W2913693754 cites W2073979520 @default.
• W2913693754 cites W2078417719 @default.
• W2913693754 cites W2084488109 @default.
• W2913693754 cites W2091620222 @default.
• W2913693754 cites W2091762710 @default.
• W2913693754 cites W2094887155 @default.
• W2913693754 cites W2098660078 @default.
• W2913693754 cites W2101680415 @default.
• W2913693754 cites W2107197062 @default.
• W2913693754 cites W2109002457 @default.
• W2913693754 cites W2111251212 @default.
• W2913693754 cites W2111346020 @default.
• W2913693754 cites W2112109116 @default.
• W2913693754 cites W2113675370 @default.
• W2913693754 cites W2115070630 @default.
• W2913693754 cites W2131313431 @default.
• W2913693754 cites W2132482152 @default.
• W2913693754 cites W2138006810 @default.
• W2913693754 cites W2161451795 @default.
• W2913693754 cites W2168842577 @default.
• W2913693754 cites W2172145961 @default.
• W2913693754 cites W2192903939 @default.
• W2913693754 cites W2225389324 @default.
• W2913693754 cites W2305304932 @default.
• W2913693754 cites W2342600362 @default.
• W2913693754 cites W2398117252 @default.
• W2913693754 cites W2469395978 @default.
• W2913693754 cites W2498204441 @default.
• W2913693754 cites W2518392966 @default.
• W2913693754 cites W2519436935 @default.
• W2913693754 cites W2524461934 @default.
• W2913693754 cites W2528460349 @default.
• W2913693754 cites W2530261665 @default.
• W2913693754 cites W2550207538 @default.
• W2913693754 cites W2567018316 @default.
• W2913693754 cites W2582531027 @default.
• W2913693754 cites W2583783257 @default.
• W2913693754 cites W2598724458 @default.
• W2913693754 cites W2605508275 @default.
• W2913693754 cites W2736825224 @default.
• W2913693754 cites W2767832902 @default.
• W2913693754 cites W2768108307 @default.
• W2913693754 cites W2790485567 @default.
• W2913693754 cites W2888741274 @default.
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• W2913693754 doi "https://doi.org/10.1016/j.brainresbull.2019.02.003" @default.
• W2913693754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30769127" @default.
• W2913693754 hasPublicationYear "2019" @default.
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