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- W2913697212 abstract "Tumors can evade recognition by the immune system through downregulation of the peptide-presenting MHC-I molecules. In this thesis, we describe that these tumors can still be targeted by a novel category of CD8 T cells, recognizing a specific peptide presented on those immune-escaped tumors. We describe the selection and characteristics of these specific T cells and show they can protect against a challenge with these MHC-I low tumors. This could be a novel type of therapy for tumors which have become resistant against conventional (immune)therapies." @default.
- W2913697212 created "2019-02-21" @default.
- W2913697212 creator A5045097901 @default.
- W2913697212 date "2017-06-29" @default.
- W2913697212 modified "2023-09-24" @default.
- W2913697212 title "T cell immunity against MHC-Ilow tumors in mouse models" @default.
- W2913697212 hasPublicationYear "2017" @default.
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