Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913697977> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2913697977 endingPage "11" @default.
- W2913697977 startingPage "1" @default.
- W2913697977 abstract "Objectives: Retinoblastoma is the most common intraocular malignancy afflicting children worldwide. Even though there are enough data about the epidemiology of retinoblastoma in western population, there are only few reports from developing countries like India. In this retrospective study, we aimed to describe the epidemiological patterns, survival characteristics and prognostic factors of retinoblastoma.
 Materials and Methods: From medical records, we retrospectively analyzed the data of 68 children diagnosed in our hospital between January 2013 and December 2017 as having retinoblastoma. Data on sex, religion, laterality, age at diagnosis, presenting signs, family history, lag time for treatment, cause of such lag time and spread of tumor, treatment mode, and survival time were collected.
 Results: The median age of onset was 22 ± 19.73 months (range 2-92 months).The median patient age of onset of the unilateral cases was 23 ± 20.6 months, and that of the bilateral cases was 21 ±16.2 months. The median overall survival was 28.1±2.2 months. For unilateral cases, it was 30.1±2.5 months and for bilateral cases it was 19.7±2.9 months. The overall progression free survival (PFS) was 22.2±2.3 months. For unilateral cases, it was 24.18±2.7 months and for bilateral cases it was 13.9±2.9 months.
 4 cases of familial retinoblastoma were reported. Among the 13 bilateral cases, 3 were found to have pinealoblastoma too. On Cox regression analysis, age of onset below 36 months, diagnostic delay of less than 5 months and delay of treatment initiation (after diagnosis) less than 2 months were found to have significant effect on OS. The former two were found to have significant effect on PFS but not the latter (p<0.05 and HR>1).
 Conclusions: Almost 81% of patients presented at an advanced stage of the disease, the reason being accounted by diagnostic and therapeutic delay by virtue of a number of causes, the major one being eluded by apparently nonviolent yet ineffective alternative medicine practices. In spite of following the institutional protocols which are at par to the international guidelines, analysis shows much poorer survival in this study compared to those of developed countries. The cause might be such late presentation of the cases in already advanced stages of the disease." @default.
- W2913697977 created "2019-02-21" @default.
- W2913697977 creator A5014990154 @default.
- W2913697977 creator A5024539792 @default.
- W2913697977 creator A5040097436 @default.
- W2913697977 creator A5079263517 @default.
- W2913697977 creator A5090501156 @default.
- W2913697977 date "2019-02-15" @default.
- W2913697977 modified "2023-10-18" @default.
- W2913697977 title "Retinoblastoma – Lessons Learned about Patterns of Care and Contributory Factors from 5 Years’ Experience in a Tertiary Care Center in Eastern India" @default.
- W2913697977 doi "https://doi.org/10.9734/jcti/2018/v8i230093" @default.
- W2913697977 hasPublicationYear "2019" @default.
- W2913697977 type Work @default.
- W2913697977 sameAs 2913697977 @default.
- W2913697977 citedByCount "1" @default.
- W2913697977 countsByYear W29136979772022 @default.
- W2913697977 crossrefType "journal-article" @default.
- W2913697977 hasAuthorship W2913697977A5014990154 @default.
- W2913697977 hasAuthorship W2913697977A5024539792 @default.
- W2913697977 hasAuthorship W2913697977A5040097436 @default.
- W2913697977 hasAuthorship W2913697977A5079263517 @default.
- W2913697977 hasAuthorship W2913697977A5090501156 @default.
- W2913697977 hasBestOaLocation W29136979771 @default.
- W2913697977 hasConcept C104317684 @default.
- W2913697977 hasConcept C107130276 @default.
- W2913697977 hasConcept C126322002 @default.
- W2913697977 hasConcept C141071460 @default.
- W2913697977 hasConcept C167135981 @default.
- W2913697977 hasConcept C185592680 @default.
- W2913697977 hasConcept C187212893 @default.
- W2913697977 hasConcept C195910791 @default.
- W2913697977 hasConcept C2776577112 @default.
- W2913697977 hasConcept C2779399171 @default.
- W2913697977 hasConcept C2780073493 @default.
- W2913697977 hasConcept C2781179581 @default.
- W2913697977 hasConcept C50382708 @default.
- W2913697977 hasConcept C55493867 @default.
- W2913697977 hasConcept C71924100 @default.
- W2913697977 hasConceptScore W2913697977C104317684 @default.
- W2913697977 hasConceptScore W2913697977C107130276 @default.
- W2913697977 hasConceptScore W2913697977C126322002 @default.
- W2913697977 hasConceptScore W2913697977C141071460 @default.
- W2913697977 hasConceptScore W2913697977C167135981 @default.
- W2913697977 hasConceptScore W2913697977C185592680 @default.
- W2913697977 hasConceptScore W2913697977C187212893 @default.
- W2913697977 hasConceptScore W2913697977C195910791 @default.
- W2913697977 hasConceptScore W2913697977C2776577112 @default.
- W2913697977 hasConceptScore W2913697977C2779399171 @default.
- W2913697977 hasConceptScore W2913697977C2780073493 @default.
- W2913697977 hasConceptScore W2913697977C2781179581 @default.
- W2913697977 hasConceptScore W2913697977C50382708 @default.
- W2913697977 hasConceptScore W2913697977C55493867 @default.
- W2913697977 hasConceptScore W2913697977C71924100 @default.
- W2913697977 hasLocation W29136979771 @default.
- W2913697977 hasOpenAccess W2913697977 @default.
- W2913697977 hasPrimaryLocation W29136979771 @default.
- W2913697977 hasRelatedWork W1983777988 @default.
- W2913697977 hasRelatedWork W2080261023 @default.
- W2913697977 hasRelatedWork W2135349964 @default.
- W2913697977 hasRelatedWork W2529603326 @default.
- W2913697977 hasRelatedWork W2737200651 @default.
- W2913697977 hasRelatedWork W3127174492 @default.
- W2913697977 hasRelatedWork W3198679915 @default.
- W2913697977 hasRelatedWork W334600261 @default.
- W2913697977 hasRelatedWork W4221019750 @default.
- W2913697977 hasRelatedWork W4313418666 @default.
- W2913697977 isParatext "false" @default.
- W2913697977 isRetracted "false" @default.
- W2913697977 magId "2913697977" @default.
- W2913697977 workType "article" @default.