Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913700657> ?p ?o ?g. }
- W2913700657 abstract "The scaffold protein PAR3 and the kinase PAR1 are essential proteins that control cell polarity. Their precise opposite localisations define plasma membrane domains with specific functions. PAR3 and PAR1 are mutually inhibited by direct or indirect phosphorylations, but their fates once phosphorylated are poorly known. Through precise spatiotemporal quantification of PAR3 localisation in the Drosophila oocyte, we identify several mechanisms responsible for its anterior cortex accumulation and its posterior exclusion. We show that PAR3 posterior plasma membrane exclusion depends on PAR1 and an endocytic mechanism relying on RAB5 and PI(4,5)P2. In a second phase, microtubules and the dynein motor, in connection with vesicular trafficking involving RAB11 and IKK-related kinase, IKKε, are required for PAR3 transport towards the anterior cortex. Altogether, our results point to a connection between membrane trafficking and dynein-mediated transport to sustain PAR3 asymmetry." @default.
- W2913700657 created "2019-02-21" @default.
- W2913700657 creator A5000905507 @default.
- W2913700657 creator A5033870982 @default.
- W2913700657 creator A5077659192 @default.
- W2913700657 date "2019-01-23" @default.
- W2913700657 modified "2023-10-17" @default.
- W2913700657 title "Dynein-mediated transport and membrane trafficking control PAR3 polarised distribution" @default.
- W2913700657 cites W1541004785 @default.
- W2913700657 cites W1566790599 @default.
- W2913700657 cites W1573053105 @default.
- W2913700657 cites W1904811091 @default.
- W2913700657 cites W1966398993 @default.
- W2913700657 cites W1967976750 @default.
- W2913700657 cites W1971160209 @default.
- W2913700657 cites W1975338046 @default.
- W2913700657 cites W1976226144 @default.
- W2913700657 cites W1976995232 @default.
- W2913700657 cites W1978534363 @default.
- W2913700657 cites W1980793772 @default.
- W2913700657 cites W1982097676 @default.
- W2913700657 cites W1985255952 @default.
- W2913700657 cites W1986368793 @default.
- W2913700657 cites W1989613239 @default.
- W2913700657 cites W1990188178 @default.
- W2913700657 cites W1991222170 @default.
- W2913700657 cites W1992171856 @default.
- W2913700657 cites W2001161627 @default.
- W2913700657 cites W2003106273 @default.
- W2913700657 cites W2008462998 @default.
- W2913700657 cites W2009685064 @default.
- W2913700657 cites W2011974546 @default.
- W2913700657 cites W2015407080 @default.
- W2913700657 cites W2017522546 @default.
- W2913700657 cites W2027158136 @default.
- W2913700657 cites W2035657497 @default.
- W2913700657 cites W2049948717 @default.
- W2913700657 cites W2050876666 @default.
- W2913700657 cites W2060686949 @default.
- W2913700657 cites W2061212583 @default.
- W2913700657 cites W2065226275 @default.
- W2913700657 cites W2070467043 @default.
- W2913700657 cites W2071014556 @default.
- W2913700657 cites W2071731154 @default.
- W2913700657 cites W2074189105 @default.
- W2913700657 cites W2075640685 @default.
- W2913700657 cites W2079210215 @default.
- W2913700657 cites W2082104120 @default.
- W2913700657 cites W2082264194 @default.
- W2913700657 cites W2086481173 @default.
- W2913700657 cites W2089693405 @default.
- W2913700657 cites W2089839677 @default.
- W2913700657 cites W2093291036 @default.
- W2913700657 cites W2094625991 @default.
- W2913700657 cites W2106395514 @default.
- W2913700657 cites W2110197429 @default.
- W2913700657 cites W2117876140 @default.
- W2913700657 cites W2121706515 @default.
- W2913700657 cites W2123008200 @default.
- W2913700657 cites W2123403344 @default.
- W2913700657 cites W2125031377 @default.
- W2913700657 cites W2128680169 @default.
- W2913700657 cites W2130526838 @default.
- W2913700657 cites W2131247762 @default.
- W2913700657 cites W2132757164 @default.
- W2913700657 cites W2136388836 @default.
- W2913700657 cites W2137685927 @default.
- W2913700657 cites W2138107120 @default.
- W2913700657 cites W2139794720 @default.
- W2913700657 cites W2142606014 @default.
- W2913700657 cites W2149491013 @default.
- W2913700657 cites W2149687327 @default.
- W2913700657 cites W2151462825 @default.
- W2913700657 cites W2152138104 @default.
- W2913700657 cites W2161930851 @default.
- W2913700657 cites W2173662594 @default.
- W2913700657 cites W2183150277 @default.
- W2913700657 cites W2346126968 @default.
- W2913700657 cites W2542834860 @default.
- W2913700657 cites W2597959542 @default.
- W2913700657 cites W2761076503 @default.
- W2913700657 cites W2791140528 @default.
- W2913700657 cites W2800287140 @default.
- W2913700657 doi "https://doi.org/10.7554/elife.40212" @default.
- W2913700657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6358217" @default.
- W2913700657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30672465" @default.
- W2913700657 hasPublicationYear "2019" @default.
- W2913700657 type Work @default.
- W2913700657 sameAs 2913700657 @default.
- W2913700657 citedByCount "25" @default.
- W2913700657 countsByYear W29137006572017 @default.
- W2913700657 countsByYear W29137006572019 @default.
- W2913700657 countsByYear W29137006572020 @default.
- W2913700657 countsByYear W29137006572021 @default.
- W2913700657 countsByYear W29137006572022 @default.
- W2913700657 countsByYear W29137006572023 @default.
- W2913700657 crossrefType "journal-article" @default.
- W2913700657 hasAuthorship W2913700657A5000905507 @default.
- W2913700657 hasAuthorship W2913700657A5033870982 @default.
- W2913700657 hasAuthorship W2913700657A5077659192 @default.