FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913716462> ?p ?o ?g. }

• W2913716462 abstract "Abstract Tissue-specific establishment of repressive chromatin through creation of compact chromatin domains during development is necessary to ensure proper gene expression and cell fate. C. elegans synMuv B proteins are important for the soma/germline fate decision and mutants demonstrate ectopic germline gene expression in somatic tissue, especially at high temperature. We show that C. elegans synMuv B proteins regulate developmental chromatin compaction and that timing of chromatin compaction is temperature sensitive in both wild-type and synMuv B mutants. Chromatin compaction in mutants is delayed into developmental time-periods when zygotic gene expression is upregulated and demonstrates an anterior-to-posterior pattern. Loss of this patterned compaction coincides with the developmental time-period of ectopic germline gene expression that leads to a developmental arrest in synMuv B mutants. Thus, chromatin organization throughout development is regulated both spatially and temporally by synMuv B proteins to establish repressive chromatin in a tissue-specific manner to ensure proper gene expression." @default.
• W2913716462 created "2019-02-21" @default.
• W2913716462 creator A5006939503 @default.
• W2913716462 creator A5073502597 @default.
• W2913716462 date "2019-02-02" @default.
• W2913716462 modified "2023-10-17" @default.
• W2913716462 title "<i>C. elegans</i>synMuv B proteins regulate spatial and temporal chromatin compaction during development" @default.
• W2913716462 cites W1963690635 @default.
• W2913716462 cites W1971049411 @default.
• W2913716462 cites W1975539651 @default.
• W2913716462 cites W1975542747 @default.
• W2913716462 cites W1998060385 @default.
• W2913716462 cites W2022927779 @default.
• W2913716462 cites W2023771701 @default.
• W2913716462 cites W2024523631 @default.
• W2913716462 cites W2033160626 @default.
• W2913716462 cites W2046781332 @default.
• W2913716462 cites W2079936148 @default.
• W2913716462 cites W2088035403 @default.
• W2913716462 cites W2096474417 @default.
• W2913716462 cites W2100140713 @default.
• W2913716462 cites W2104489517 @default.
• W2913716462 cites W2106194572 @default.
• W2913716462 cites W2110359316 @default.
• W2913716462 cites W2123419812 @default.
• W2913716462 cites W2124307323 @default.
• W2913716462 cites W2125256388 @default.
• W2913716462 cites W2128541738 @default.
• W2913716462 cites W2131638796 @default.
• W2913716462 cites W2135204824 @default.
• W2913716462 cites W2142603647 @default.
• W2913716462 cites W2148966035 @default.
• W2913716462 cites W2149869194 @default.
• W2913716462 cites W2153265357 @default.
• W2913716462 cites W2155557838 @default.
• W2913716462 cites W2155696254 @default.
• W2913716462 cites W2156397151 @default.
• W2913716462 cites W2156726420 @default.
• W2913716462 cites W2165970635 @default.
• W2913716462 cites W2170728578 @default.
• W2913716462 cites W2174420796 @default.
• W2913716462 cites W2281019288 @default.
• W2913716462 cites W2432996297 @default.
• W2913716462 cites W2586812692 @default.
• W2913716462 cites W2593551397 @default.
• W2913716462 cites W2611331868 @default.
• W2913716462 cites W2735414420 @default.
• W2913716462 cites W2766540549 @default.
• W2913716462 cites W2786896132 @default.
• W2913716462 cites W2895144600 @default.
• W2913716462 cites W2904156351 @default.
• W2913716462 cites W2953341765 @default.
• W2913716462 doi "https://doi.org/10.1101/538801" @default.
• W2913716462 hasPublicationYear "2019" @default.
• W2913716462 type Work @default.
• W2913716462 sameAs 2913716462 @default.
• W2913716462 citedByCount "2" @default.
• W2913716462 countsByYear W29137164622019 @default.
• W2913716462 crossrefType "posted-content" @default.
• W2913716462 hasAuthorship W2913716462A5006939503 @default.
• W2913716462 hasAuthorship W2913716462A5073502597 @default.
• W2913716462 hasBestOaLocation W29137164621 @default.
• W2913716462 hasConcept C104317684 @default.
• W2913716462 hasConcept C109825262 @default.
• W2913716462 hasConcept C134305767 @default.
• W2913716462 hasConcept C143065580 @default.
• W2913716462 hasConcept C150194340 @default.
• W2913716462 hasConcept C163952510 @default.
• W2913716462 hasConcept C167227067 @default.
• W2913716462 hasConcept C196843134 @default.
• W2913716462 hasConcept C28748434 @default.
• W2913716462 hasConcept C54355233 @default.
• W2913716462 hasConcept C83640560 @default.
• W2913716462 hasConcept C86339819 @default.
• W2913716462 hasConcept C86803240 @default.
• W2913716462 hasConcept C87073359 @default.
• W2913716462 hasConcept C95444343 @default.
• W2913716462 hasConcept C97037327 @default.
• W2913716462 hasConceptScore W2913716462C104317684 @default.
• W2913716462 hasConceptScore W2913716462C109825262 @default.
• W2913716462 hasConceptScore W2913716462C134305767 @default.
• W2913716462 hasConceptScore W2913716462C143065580 @default.
• W2913716462 hasConceptScore W2913716462C150194340 @default.
• W2913716462 hasConceptScore W2913716462C163952510 @default.
• W2913716462 hasConceptScore W2913716462C167227067 @default.
• W2913716462 hasConceptScore W2913716462C196843134 @default.
• W2913716462 hasConceptScore W2913716462C28748434 @default.
• W2913716462 hasConceptScore W2913716462C54355233 @default.
• W2913716462 hasConceptScore W2913716462C83640560 @default.
• W2913716462 hasConceptScore W2913716462C86339819 @default.
• W2913716462 hasConceptScore W2913716462C86803240 @default.
• W2913716462 hasConceptScore W2913716462C87073359 @default.
• W2913716462 hasConceptScore W2913716462C95444343 @default.
• W2913716462 hasConceptScore W2913716462C97037327 @default.
• W2913716462 hasLocation W29137164621 @default.
• W2913716462 hasLocation W29137164622 @default.
• W2913716462 hasLocation W29137164623 @default.
• W2913716462 hasOpenAccess W2913716462 @default.
• W2913716462 hasPrimaryLocation W29137164621 @default.
• W2913716462 hasRelatedWork W1974822125 @default.

• next