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- W2913737580 abstract "We sought to compare characteristics of anaphylaxis between children in the first two years of life and older children up to eighteen years of age. Children presenting with anaphylaxis to Emergency Departments (ED) in five Canadian provinces were recruited into the Cross-Canada Anaphylaxis Registry. A standardised form documenting anaphylaxis was completed by research teams. Moderate anaphylaxis was defined by crampy abdominal pain, diarrhea, recurrent vomiting, dyspnea, stridor, cough, wheeze, or “light-headedness”. Severe anaphylaxis was defined by the presence of cyanosis/hypoxia, respiratory arrest, hypotension, dysrhythmia, confusion, or loss of consciousness. Chi-squared tests were used to compare anaphylaxis severity, clinical presentation, management and triggers between younger and older children. Between July 2012 and October 2017 in participating ED’s,we recorded 694 cases of anaphylaxis in children less than 2 years and 2117 cases in older children. The median age in younger children was 1 year (Interquartile range (IQR) 0.7-1.5) and older children was 5.5 years (IQR 2.1-11.2). Older children were more likely to have moderate-severe anaphylaxis (82% vs 68%, p=0.001), respiratory symptoms (38% vs 29%, p=0.001) or be treated with epinephrine (78% vs 68%, p=0.0001). Presenting gastrointestinal symptoms were similar in both groups (41% vs 41%). Egg, peanut and milk were the more frequent trigger foods in younger children compared to older children (21% vs 3%, p=0.001), (21% vs 18%, p=0.09), (10% vs 5%, p=0.001) respectively. Characteristics of anaphylaxis differ between young and older children. These factors may inform clinicians in optimizing management of anaphylaxis presentations in childhood." @default.
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- W2913737580 date "2019-02-01" @default.
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- W2913737580 title "Anaphylaxis: comparison of clinical characteristics and management between children less than 2 years of age and older children" @default.
- W2913737580 doi "https://doi.org/10.1016/j.jaci.2018.12.440" @default.
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