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- W2913743011 abstract "Detecting and characterizing polymers with a nanopore sensor requires a significant interaction between the polymer and nanopore in order for the polymer to yield measurable current blockades. To design a selective nanopore sensor, quantitative measurement of the free energy profile including the contributions of both entropy and enthalpy is essential. We have developed a laser-based tool to rapidly control the solution temperature of an alpha-hemolysin nanopore sensor, resulting in nearly continuous Arrhenius plots in less than 2 min. By combing these measurements with the observation of the partition coefficient and capture rates, we have generated a full picture of the energetics of a nanopore sensor. Using this method, we show that poly(ethylene glycol detection is dominated by entropy due tension along the polymer while it transits steep electric field gradient of the pore entrance and exit. In contrast, model peptides represented by angiotensin 1, angiotensin 2 and neurotensin are regulated by hydrogen-bonding (i.e., enthalpy) within the pore. Although the total free energy for each system is similar, these polymers present completely different chemistry to the pore. These results provide a rich chemical description of two chemically distinct systems and provide guidance for developing nanopore sensors with designed chemical selectivity." @default.
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- W2913743011 date "2021-02-01" @default.
- W2913743011 modified "2023-09-27" @default.
- W2913743011 title "Temperature Studies Reveal the Roles of Entropy and Enthalpy in Polymer-Nanopore Interactions" @default.
- W2913743011 doi "https://doi.org/10.1016/j.bpj.2020.11.1735" @default.
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