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- W2913752615 endingPage "480" @default.
- W2913752615 startingPage "441" @default.
- W2913752615 abstract "Abstract Antibody–drug conjugates (ADCs) are designed with the purpose of delivering small-molecule cytotoxic drug to antigen-expressing tumor cells by harnessing the specificity, biodistribution, and pharmacokinetics of antibodies. ADCs are comprised of three components: the antibody, the linker, and the cytotoxic agent. To achieve the desired goal of targeted therapy with anticipated efficacy and safety profiles, each ADC component must be carefully selected and optimized. In this chapter, we introduce the main concepts and technologies associated with clinical development of ADCs. Considerations regarding ADC production such as drug–antibody conjugation, linker technologies, and cytotoxic agents are discussed. In addition, we describe analytical methods to characterize ADC products for assessment of drug content and purity. Finally, mechanistic aspects ADCs in vivo and the underlying key factors effecting on- and off-target toxicities are introduced." @default.
- W2913752615 created "2019-02-21" @default.
- W2913752615 creator A5018129304 @default.
- W2913752615 creator A5037578140 @default.
- W2913752615 creator A5073559624 @default.
- W2913752615 creator A5076501775 @default.
- W2913752615 creator A5087819473 @default.
- W2913752615 date "2017-01-01" @default.
- W2913752615 modified "2023-10-18" @default.
- W2913752615 title "Antibody-Drug Conjugates" @default.
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