Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913753284> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2913753284 abstract "The heterodimeric complex, formed by Toll-Like Receptor 4 (TLR4) and its accessory protein Myeloid Differentiation factor 2 (MD-2) is responsible of activating the innate immune system when sensing the presence of particular pathogen-associated molecular patterns (PAMPs) from bacteria. The outer membrane of Gram-negative bacteria is primarily populated by lipopolysaccharides (LPS) which are essential for their growth and survival. These LPSs are specifically recognized by the TLR4/MD-2 complex as follows: an LPS binds to MD-2 inside a deep molecular hydrophobic pocket causing molecular rearrangements of the receptorial complex resulting in the dimerization of another TLR4/MD-2 unit. TLR4 ectodomains dimerization event brings together the TLR4 intercellular domains initiating the activation of innate immune system signaling pathways. Interestingly, this activation is not only modulated by naturally occurring LPSs from many different Gram-negative bacteria but also by non-naturally occurring glycolipids and other non-LPS like molecules..." @default.
- W2913753284 created "2019-02-21" @default.
- W2913753284 creator A5043150071 @default.
- W2913753284 date "2018-05-04" @default.
- W2913753284 modified "2023-09-28" @default.
- W2913753284 title "TLR4 modulation: molecular recognition studies and drug design by molecular modelling" @default.
- W2913753284 hasPublicationYear "2018" @default.
- W2913753284 type Work @default.
- W2913753284 sameAs 2913753284 @default.
- W2913753284 citedByCount "0" @default.
- W2913753284 crossrefType "dissertation" @default.
- W2913753284 hasAuthorship W2913753284A5043150071 @default.
- W2913753284 hasConcept C104317684 @default.
- W2913753284 hasConcept C111289621 @default.
- W2913753284 hasConcept C136449434 @default.
- W2913753284 hasConcept C146587185 @default.
- W2913753284 hasConcept C170493617 @default.
- W2913753284 hasConcept C178790620 @default.
- W2913753284 hasConcept C179303850 @default.
- W2913753284 hasConcept C185592680 @default.
- W2913753284 hasConcept C188899842 @default.
- W2913753284 hasConcept C203014093 @default.
- W2913753284 hasConcept C2776070231 @default.
- W2913753284 hasConcept C2776709828 @default.
- W2913753284 hasConcept C32909587 @default.
- W2913753284 hasConcept C523546767 @default.
- W2913753284 hasConcept C54355233 @default.
- W2913753284 hasConcept C547475151 @default.
- W2913753284 hasConcept C55493867 @default.
- W2913753284 hasConcept C62478195 @default.
- W2913753284 hasConcept C79879829 @default.
- W2913753284 hasConcept C86803240 @default.
- W2913753284 hasConcept C8891405 @default.
- W2913753284 hasConcept C95444343 @default.
- W2913753284 hasConceptScore W2913753284C104317684 @default.
- W2913753284 hasConceptScore W2913753284C111289621 @default.
- W2913753284 hasConceptScore W2913753284C136449434 @default.
- W2913753284 hasConceptScore W2913753284C146587185 @default.
- W2913753284 hasConceptScore W2913753284C170493617 @default.
- W2913753284 hasConceptScore W2913753284C178790620 @default.
- W2913753284 hasConceptScore W2913753284C179303850 @default.
- W2913753284 hasConceptScore W2913753284C185592680 @default.
- W2913753284 hasConceptScore W2913753284C188899842 @default.
- W2913753284 hasConceptScore W2913753284C203014093 @default.
- W2913753284 hasConceptScore W2913753284C2776070231 @default.
- W2913753284 hasConceptScore W2913753284C2776709828 @default.
- W2913753284 hasConceptScore W2913753284C32909587 @default.
- W2913753284 hasConceptScore W2913753284C523546767 @default.
- W2913753284 hasConceptScore W2913753284C54355233 @default.
- W2913753284 hasConceptScore W2913753284C547475151 @default.
- W2913753284 hasConceptScore W2913753284C55493867 @default.
- W2913753284 hasConceptScore W2913753284C62478195 @default.
- W2913753284 hasConceptScore W2913753284C79879829 @default.
- W2913753284 hasConceptScore W2913753284C86803240 @default.
- W2913753284 hasConceptScore W2913753284C8891405 @default.
- W2913753284 hasConceptScore W2913753284C95444343 @default.
- W2913753284 hasLocation W29137532841 @default.
- W2913753284 hasOpenAccess W2913753284 @default.
- W2913753284 hasPrimaryLocation W29137532841 @default.
- W2913753284 hasRelatedWork W1896283776 @default.
- W2913753284 hasRelatedWork W1912852347 @default.
- W2913753284 hasRelatedWork W1971122967 @default.
- W2913753284 hasRelatedWork W1974055405 @default.
- W2913753284 hasRelatedWork W1989795794 @default.
- W2913753284 hasRelatedWork W2009034382 @default.
- W2913753284 hasRelatedWork W2011318392 @default.
- W2913753284 hasRelatedWork W2016862474 @default.
- W2913753284 hasRelatedWork W2019608583 @default.
- W2913753284 hasRelatedWork W2036853809 @default.
- W2913753284 hasRelatedWork W2041209085 @default.
- W2913753284 hasRelatedWork W2062563033 @default.
- W2913753284 hasRelatedWork W2063585986 @default.
- W2913753284 hasRelatedWork W2066582344 @default.
- W2913753284 hasRelatedWork W2111427115 @default.
- W2913753284 hasRelatedWork W2885082572 @default.
- W2913753284 hasRelatedWork W3047476416 @default.
- W2913753284 hasRelatedWork W44092347 @default.
- W2913753284 hasRelatedWork W90612005 @default.
- W2913753284 hasRelatedWork W957495929 @default.
- W2913753284 isParatext "false" @default.
- W2913753284 isRetracted "false" @default.
- W2913753284 magId "2913753284" @default.
- W2913753284 workType "dissertation" @default.