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• W2913760105 abstract "Covalently closed single-stranded circular RNAs (circRNAs) consist of introns or exons and are widely present in eukaryotic cells. CircRNAs generally have low expression levels and relatively stable structures compared with messenger RNAs (mRNAs), most of which are located in the cytoplasm and often act in cell type and tissue-specific manners, indicating that they may serve as novel biomarkers. In recent years, circRNAs have gradually become a hotspot in the field of RNA and cancer research, but the functions of most circRNAs have not yet been discovered. Known circRNAs can affect the biogenesis of cancers in diverse ways, such as functioning as a microRNA (miRNA) sponges, combining with RNA binding proteins (RBPs), working as a transcription factor and translation of proteins. In this review, we summarize the characteristics and types of circRNAs, introduce the biogenesis of circRNAs, discuss the emerging functions and databases on circRNAs and present the current challenges of circRNAs studies." @default.
• W2913760105 created "2019-02-21" @default.
• W2913760105 creator A5014484076 @default.
• W2913760105 creator A5055480093 @default.
• W2913760105 creator A5061702878 @default.
• W2913760105 creator A5085206645 @default.
• W2913760105 date "2019-01-09" @default.
• W2913760105 modified "2023-10-17" @default.
• W2913760105 title "The novel roles of circRNAs in human cancer" @default.
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• W2913760105 doi "https://doi.org/10.1186/s12943-018-0934-6" @default.
• W2913760105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6325800" @default.
• W2913760105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30626395" @default.
• W2913760105 hasPublicationYear "2019" @default.
• W2913760105 type Work @default.
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