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- W2913761454 endingPage "566" @default.
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- W2913761454 abstract "Abstract Chemokines orchestrate leukocyte recruitment in atherosclerosis and their blockade is a promising anti-atherosclerotic strategy, but few chemokine-based approaches have advanced into clinical trials, in part owing to the complexity and redundancy of the chemokine network. Macrophage migration inhibitory factor (MIF) is a pivotal mediator of atherosclerotic lesion formation. It has been characterized as an inflammatory cytokine and atypical chemokine that promotes atherogenic leukocyte recruitment and lesional inflammation through interactions with the chemokine receptors CXCR2 and CXCR4, but also exhibits phase-specific CD74-mediated cardioprotective activity. The unique structural properties of MIF and its homologue MIF-2/D-DT offer intriguing therapeutic opportunities including small molecule-, antibody- and peptide-based approaches that may hold promise as inhibitors of atherosclerosis, while sparing tissue-protective classical chemokine pathways. In this review, we summarize the pros and cons of anti-MIF protein strategies and discuss their molecular characteristics and receptor specificities with a focus on cardiovascular disease." @default.
- W2913761454 created "2019-02-21" @default.
- W2913761454 creator A5001664185 @default.
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- W2913761454 creator A5032494718 @default.
- W2913761454 creator A5036306637 @default.
- W2913761454 creator A5075134904 @default.
- W2913761454 date "2019-02-04" @default.
- W2913761454 modified "2023-10-12" @default.
- W2913761454 title "Macrophage Migration Inhibitory Factor (MIF)-Based Therapeutic Concepts in Atherosclerosis and Inflammation" @default.
- W2913761454 cites W146135169 @default.
- W2913761454 cites W1485720010 @default.
- W2913761454 cites W1549815504 @default.
- W2913761454 cites W1574734561 @default.
- W2913761454 cites W1642259399 @default.
- W2913761454 cites W1734802175 @default.
- W2913761454 cites W1840986526 @default.
- W2913761454 cites W1874492336 @default.
- W2913761454 cites W1877968105 @default.
- W2913761454 cites W1890667195 @default.
- W2913761454 cites W1922705469 @default.
- W2913761454 cites W1934054475 @default.
- W2913761454 cites W1940345635 @default.
- W2913761454 cites W1964083898 @default.
- W2913761454 cites W1964366119 @default.
- W2913761454 cites W1964601428 @default.
- W2913761454 cites W1970596902 @default.
- W2913761454 cites W1973610607 @default.
- W2913761454 cites W1974433996 @default.
- W2913761454 cites W1975349664 @default.
- W2913761454 cites W1986837253 @default.
- W2913761454 cites W1987308393 @default.
- W2913761454 cites W1989832114 @default.
- W2913761454 cites W1991707658 @default.
- W2913761454 cites W1991922050 @default.
- W2913761454 cites W1992450378 @default.
- W2913761454 cites W1992726653 @default.
- W2913761454 cites W1992822564 @default.
- W2913761454 cites W1994803737 @default.
- W2913761454 cites W1995147982 @default.
- W2913761454 cites W1996054510 @default.
- W2913761454 cites W1997868017 @default.
- W2913761454 cites W1998389471 @default.
- W2913761454 cites W1999787339 @default.
- W2913761454 cites W2000541661 @default.
- W2913761454 cites W2004840822 @default.
- W2913761454 cites W2008842656 @default.
- W2913761454 cites W2009141321 @default.
- W2913761454 cites W2013839742 @default.
- W2913761454 cites W2017357058 @default.
- W2913761454 cites W2017765834 @default.
- W2913761454 cites W2018237850 @default.
- W2913761454 cites W2019535641 @default.
- W2913761454 cites W2020228504 @default.
- W2913761454 cites W2021256296 @default.
- W2913761454 cites W2021517381 @default.
- W2913761454 cites W2023776704 @default.
- W2913761454 cites W2023837865 @default.
- W2913761454 cites W2024984008 @default.
- W2913761454 cites W2026192283 @default.
- W2913761454 cites W2026749159 @default.
- W2913761454 cites W2029174607 @default.
- W2913761454 cites W2029479572 @default.
- W2913761454 cites W2032555624 @default.
- W2913761454 cites W2032811951 @default.
- W2913761454 cites W2035192731 @default.
- W2913761454 cites W2039411604 @default.
- W2913761454 cites W2040210877 @default.
- W2913761454 cites W2047297009 @default.
- W2913761454 cites W2049780044 @default.
- W2913761454 cites W2051137913 @default.
- W2913761454 cites W2051318436 @default.
- W2913761454 cites W2051521455 @default.
- W2913761454 cites W2054140923 @default.
- W2913761454 cites W2055862301 @default.
- W2913761454 cites W2057846421 @default.
- W2913761454 cites W2061631515 @default.
- W2913761454 cites W2062824264 @default.
- W2913761454 cites W2066255007 @default.
- W2913761454 cites W2067583186 @default.
- W2913761454 cites W2073054137 @default.
- W2913761454 cites W2075894073 @default.
- W2913761454 cites W2076093607 @default.
- W2913761454 cites W2079638142 @default.
- W2913761454 cites W2079721567 @default.
- W2913761454 cites W2083244808 @default.
- W2913761454 cites W2084699359 @default.
- W2913761454 cites W2086044289 @default.
- W2913761454 cites W2087441379 @default.
- W2913761454 cites W2090056328 @default.
- W2913761454 cites W2090687004 @default.
- W2913761454 cites W2090754742 @default.
- W2913761454 cites W2091791851 @default.
- W2913761454 cites W2094629035 @default.
- W2913761454 cites W2099981942 @default.
- W2913761454 cites W2102314323 @default.
- W2913761454 cites W2106219216 @default.