Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913761603> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2913761603 endingPage "184a" @default.
- W2913761603 startingPage "184a" @default.
- W2913761603 abstract "Identification of selective and vital protein targets in insect species at the molecular level and knowledge about these targets is the prime and crucial step in the comprehensive strategy of knowledge-based, target-oriented design of selective and efficient insecticides. In this context, our research has identified the insecticide DDT target as the OSCP (Oligomycin sensitivity conferring protein) and subunit “d” of the insect (Apis mellifera) ATP synthase. These two subunits of the insect enzyme differ in their content of amino acids from that of bovine heart enzyme, which is insensitive to DDT. The OSCP of the bee's ATP synthase contained 207 acids compared to 190 in bovine and the identities were only 47%. Subunit “d” of the bees had no counterpart in the bovine. Both subunits, the OSCP and subunit “d” are components of the peripheral stalk (the stator) of the ATP synthase. Interaction of DDT with OSCP and/or subunit “d” would interrupt such structure, freeze the mechanical rotation of the enzyme and block synthesis of ATP. The DDT pocket “niche” may include a structure provided by the two protein subunits. Subunit “d” and the “OSCP”. The two proteins are rich in hydrophobic amino acids, which comprise about 30% of subunit “d” and 50% of the OSCP, (amino acid sequences will be provided) that would facilitate their association with the hydrophobic structure of DDT. Identification of this essential biochemical target in insects is the first step to design selective and efficient insecticides." @default.
- W2913761603 created "2019-02-21" @default.
- W2913761603 creator A5084550094 @default.
- W2913761603 date "2019-02-01" @default.
- W2913761603 modified "2023-09-30" @default.
- W2913761603 title "Bioinformatics of New Selective Insecticide Target in Insect Species" @default.
- W2913761603 doi "https://doi.org/10.1016/j.bpj.2018.11.1023" @default.
- W2913761603 hasPublicationYear "2019" @default.
- W2913761603 type Work @default.
- W2913761603 sameAs 2913761603 @default.
- W2913761603 citedByCount "0" @default.
- W2913761603 crossrefType "journal-article" @default.
- W2913761603 hasAuthorship W2913761603A5084550094 @default.
- W2913761603 hasBestOaLocation W29137616031 @default.
- W2913761603 hasConcept C104292427 @default.
- W2913761603 hasConcept C104317684 @default.
- W2913761603 hasConcept C112243037 @default.
- W2913761603 hasConcept C151730666 @default.
- W2913761603 hasConcept C181199279 @default.
- W2913761603 hasConcept C18903297 @default.
- W2913761603 hasConcept C2777612826 @default.
- W2913761603 hasConcept C2779343474 @default.
- W2913761603 hasConcept C515207424 @default.
- W2913761603 hasConcept C55493867 @default.
- W2913761603 hasConcept C86803240 @default.
- W2913761603 hasConceptScore W2913761603C104292427 @default.
- W2913761603 hasConceptScore W2913761603C104317684 @default.
- W2913761603 hasConceptScore W2913761603C112243037 @default.
- W2913761603 hasConceptScore W2913761603C151730666 @default.
- W2913761603 hasConceptScore W2913761603C181199279 @default.
- W2913761603 hasConceptScore W2913761603C18903297 @default.
- W2913761603 hasConceptScore W2913761603C2777612826 @default.
- W2913761603 hasConceptScore W2913761603C2779343474 @default.
- W2913761603 hasConceptScore W2913761603C515207424 @default.
- W2913761603 hasConceptScore W2913761603C55493867 @default.
- W2913761603 hasConceptScore W2913761603C86803240 @default.
- W2913761603 hasIssue "3" @default.
- W2913761603 hasLocation W29137616031 @default.
- W2913761603 hasOpenAccess W2913761603 @default.
- W2913761603 hasPrimaryLocation W29137616031 @default.
- W2913761603 hasRelatedWork W1550996414 @default.
- W2913761603 hasRelatedWork W158286486 @default.
- W2913761603 hasRelatedWork W1969451414 @default.
- W2913761603 hasRelatedWork W2004312381 @default.
- W2913761603 hasRelatedWork W2013706919 @default.
- W2913761603 hasRelatedWork W2043316009 @default.
- W2913761603 hasRelatedWork W2416306772 @default.
- W2913761603 hasRelatedWork W2809277775 @default.
- W2913761603 hasRelatedWork W2900504840 @default.
- W2913761603 hasRelatedWork W3131068657 @default.
- W2913761603 hasVolume "116" @default.
- W2913761603 isParatext "false" @default.
- W2913761603 isRetracted "false" @default.
- W2913761603 magId "2913761603" @default.
- W2913761603 workType "article" @default.