FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913774265> ?p ?o ?g. }

• W2913774265 endingPage "210" @default.
• W2913774265 startingPage "203" @default.
• W2913774265 abstract "Fenofibric acid (FA) is antihyperlipidemic agent and commercially available as a tablet formulation that weighs 840 mg for 105 mg of active substance. A new formulation with less inactive substance was developed as an alternative to the conventional formulation. The purpose of this study was to evaluate the dissolution and the relative bioavailability of the surface solid dispersion (SSD) and conventional formulations of FA by comparing them with the reference formulation in its commercial tablets. The in vitro-in vivo correlation among these tablet formulations was also evaluated.The dissolution study was performed in phosphate buffer pH 6.8 and biorelevant fasted state simulated intestinal fluid. Dissolution efficiency and mean dissolution time (MDT) were used to compare the dissolution profiles. The bioavailability study, using nine healthy volunteers, was conducted based on a single-dose, fasted, randomized, crossover design. The in vivo performance was compared using the pharmacokinetic parameters Cmax, Tmax, AUC0-72, and AUC0-∞. A linear correlation model was tested using MDT and mean residence time (MRT).The results indicated that there were significant differences in the dissolution performances but no significant differences among the mean Cmax, Tmax, AUC0-72, or AUC0-∞ estimated from the SSD, conventional, and reference formulations. A poor correlation was found between MRT and MDT of the three formulations.The SSD formulation led to an instantaneous dissolution of the drug due to the presence of the polymer and the physical structure of the SSD. The conventional formulation could not achieve rapid dissolution despite its satisfying the requirement for immediate drug release dosage form. Both formulations could be considered bioequivalent with the reference. The in vitro dissolution behavior of FA using a single medium did not reflect their in vivo properties in the fasted condition. There was no correlation between the in vitro dissolution and the in vivo bioavailability of FA in this condition." @default.
• W2913774265 created "2019-02-21" @default.
• W2913774265 creator A5008293350 @default.
• W2913774265 creator A5036677101 @default.
• W2913774265 creator A5066265901 @default.
• W2913774265 date "2020-04-01" @default.
• W2913774265 modified "2023-10-10" @default.
• W2913774265 title "Comparative <i>In Vitro</i> and <i>In Vivo</i> Evaluation of Fenofibric Acid as an Antihyperlipidemic Drug" @default.
• W2913774265 cites W1762292856 @default.
• W2913774265 cites W1967067985 @default.
• W2913774265 cites W1996491239 @default.
• W2913774265 cites W2005965794 @default.
• W2913774265 cites W2011523341 @default.
• W2913774265 cites W2019277539 @default.
• W2913774265 cites W2066922931 @default.
• W2913774265 cites W2135130257 @default.
• W2913774265 cites W2305000682 @default.
• W2913774265 cites W2517792467 @default.
• W2913774265 cites W3151960558 @default.
• W2913774265 cites W362884746 @default.
• W2913774265 cites W4252133599 @default.
• W2913774265 doi "https://doi.org/10.4274/tjps.galenos.2019.27147" @default.
• W2913774265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7227912" @default.
• W2913774265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32454781" @default.
• W2913774265 hasPublicationYear "2020" @default.
• W2913774265 type Work @default.
• W2913774265 sameAs 2913774265 @default.
• W2913774265 citedByCount "5" @default.
• W2913774265 countsByYear W29137742652021 @default.
• W2913774265 countsByYear W29137742652022 @default.
• W2913774265 countsByYear W29137742652023 @default.
• W2913774265 crossrefType "journal-article" @default.
• W2913774265 hasAuthorship W2913774265A5008293350 @default.
• W2913774265 hasAuthorship W2913774265A5036677101 @default.
• W2913774265 hasAuthorship W2913774265A5066265901 @default.
• W2913774265 hasBestOaLocation W29137742651 @default.
• W2913774265 hasConcept C112705442 @default.
• W2913774265 hasConcept C14029885 @default.
• W2913774265 hasConcept C142724271 @default.
• W2913774265 hasConcept C150903083 @default.
• W2913774265 hasConcept C178790620 @default.
• W2913774265 hasConcept C181389837 @default.
• W2913774265 hasConcept C185592680 @default.
• W2913774265 hasConcept C204787440 @default.
• W2913774265 hasConcept C207001950 @default.
• W2913774265 hasConcept C22979827 @default.
• W2913774265 hasConcept C27081682 @default.
• W2913774265 hasConcept C2781430271 @default.
• W2913774265 hasConcept C33923547 @default.
• W2913774265 hasConcept C42404028 @default.
• W2913774265 hasConcept C43617362 @default.
• W2913774265 hasConcept C71924100 @default.
• W2913774265 hasConcept C77281830 @default.
• W2913774265 hasConcept C86803240 @default.
• W2913774265 hasConcept C87813604 @default.
• W2913774265 hasConcept C88380143 @default.
• W2913774265 hasConcept C98274493 @default.
• W2913774265 hasConceptScore W2913774265C112705442 @default.
• W2913774265 hasConceptScore W2913774265C14029885 @default.
• W2913774265 hasConceptScore W2913774265C142724271 @default.
• W2913774265 hasConceptScore W2913774265C150903083 @default.
• W2913774265 hasConceptScore W2913774265C178790620 @default.
• W2913774265 hasConceptScore W2913774265C181389837 @default.
• W2913774265 hasConceptScore W2913774265C185592680 @default.
• W2913774265 hasConceptScore W2913774265C204787440 @default.
• W2913774265 hasConceptScore W2913774265C207001950 @default.
• W2913774265 hasConceptScore W2913774265C22979827 @default.
• W2913774265 hasConceptScore W2913774265C27081682 @default.
• W2913774265 hasConceptScore W2913774265C2781430271 @default.
• W2913774265 hasConceptScore W2913774265C33923547 @default.
• W2913774265 hasConceptScore W2913774265C42404028 @default.
• W2913774265 hasConceptScore W2913774265C43617362 @default.
• W2913774265 hasConceptScore W2913774265C71924100 @default.
• W2913774265 hasConceptScore W2913774265C77281830 @default.
• W2913774265 hasConceptScore W2913774265C86803240 @default.
• W2913774265 hasConceptScore W2913774265C87813604 @default.
• W2913774265 hasConceptScore W2913774265C88380143 @default.
• W2913774265 hasConceptScore W2913774265C98274493 @default.
• W2913774265 hasIssue "2" @default.
• W2913774265 hasLocation W29137742651 @default.
• W2913774265 hasLocation W29137742652 @default.
• W2913774265 hasLocation W29137742653 @default.
• W2913774265 hasLocation W29137742654 @default.
• W2913774265 hasOpenAccess W2913774265 @default.
• W2913774265 hasPrimaryLocation W29137742651 @default.
• W2913774265 hasRelatedWork W124377181 @default.
• W2913774265 hasRelatedWork W151882183 @default.
• W2913774265 hasRelatedWork W2025400670 @default.
• W2913774265 hasRelatedWork W2087796686 @default.
• W2913774265 hasRelatedWork W2431224659 @default.
• W2913774265 hasRelatedWork W2770000770 @default.
• W2913774265 hasRelatedWork W2787516851 @default.
• W2913774265 hasRelatedWork W2950351041 @default.
• W2913774265 hasRelatedWork W4320723520 @default.
• W2913774265 hasRelatedWork W2187179074 @default.
• W2913774265 hasVolume "17" @default.
• W2913774265 isParatext "false" @default.
• W2913774265 isRetracted "false" @default.

• next