Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913784281> ?p ?o ?g. }
- W2913784281 abstract "Antibody deficiency or hypogammaglobulinemia can have primary or secondary etiologies. Primary antibody deficiency (PAD) is the result of intrinsic genetic defects, whereas secondary antibody deficiency may arise as a consequence of underlying conditions or medication use. On a global level, malnutrition, HIV, and malaria are major causes of secondary immunodeficiency. In this review we consider secondary antibody deficiency, for which common causes include hematological malignancies, such as chronic lymphocytic leukemia or multiple myeloma, and their treatment, protein-losing states, and side effects of a number of immunosuppressive agents and procedures involved in solid organ transplantation. Secondary antibody deficiency is not only much more common than PAD, but is also being increasingly recognized with the wider and more prolonged use of a growing list of agents targeting B cells. SAD may thus present to a broad range of specialties and is associated with an increased risk of infection. Early diagnosis and intervention is key to avoiding morbidity and mortality. Optimizing treatment requires careful clinical and laboratory assessment and may involve close monitoring of risk parameters, vaccination, antibiotic strategies, and in some patients, immunoglobulin replacement therapy (IgRT). This review discusses the rapidly evolving list of underlying causes of secondary antibody deficiency, specifically focusing on therapies targeting B cells, alongside recent advances in screening, biomarkers of risk for the development of secondary antibody deficiency, diagnosis, monitoring, and management." @default.
- W2913784281 created "2019-02-21" @default.
- W2913784281 creator A5005453736 @default.
- W2913784281 creator A5027142622 @default.
- W2913784281 creator A5082378958 @default.
- W2913784281 date "2019-02-08" @default.
- W2913784281 modified "2023-10-17" @default.
- W2913784281 title "The Expanding Field of Secondary Antibody Deficiency: Causes, Diagnosis, and Management" @default.
- W2913784281 cites W142612783 @default.
- W2913784281 cites W1510212726 @default.
- W2913784281 cites W1521244466 @default.
- W2913784281 cites W1538324437 @default.
- W2913784281 cites W1566174797 @default.
- W2913784281 cites W1582023997 @default.
- W2913784281 cites W1582717102 @default.
- W2913784281 cites W1588690200 @default.
- W2913784281 cites W1652685294 @default.
- W2913784281 cites W1654566842 @default.
- W2913784281 cites W1670276489 @default.
- W2913784281 cites W1688265474 @default.
- W2913784281 cites W1753515503 @default.
- W2913784281 cites W1778940458 @default.
- W2913784281 cites W1879924588 @default.
- W2913784281 cites W1891620832 @default.
- W2913784281 cites W1943878720 @default.
- W2913784281 cites W1964296760 @default.
- W2913784281 cites W1966356231 @default.
- W2913784281 cites W1967101890 @default.
- W2913784281 cites W1968476672 @default.
- W2913784281 cites W1971916249 @default.
- W2913784281 cites W1973178613 @default.
- W2913784281 cites W1973931325 @default.
- W2913784281 cites W1975329044 @default.
- W2913784281 cites W1978643311 @default.
- W2913784281 cites W1980884743 @default.
- W2913784281 cites W1984037973 @default.
- W2913784281 cites W1985877668 @default.
- W2913784281 cites W1989300765 @default.
- W2913784281 cites W1990890427 @default.
- W2913784281 cites W1991577923 @default.
- W2913784281 cites W1992767609 @default.
- W2913784281 cites W1993075954 @default.
- W2913784281 cites W1996815863 @default.
- W2913784281 cites W2005539485 @default.
- W2913784281 cites W2008515564 @default.
- W2913784281 cites W2008925400 @default.
- W2913784281 cites W2009638683 @default.
- W2913784281 cites W2011191551 @default.
- W2913784281 cites W2011342000 @default.
- W2913784281 cites W2012837057 @default.
- W2913784281 cites W2013176883 @default.
- W2913784281 cites W2015120596 @default.
- W2913784281 cites W2015436132 @default.
- W2913784281 cites W2023068069 @default.
- W2913784281 cites W2023846447 @default.
- W2913784281 cites W2024266233 @default.
- W2913784281 cites W2024840191 @default.
- W2913784281 cites W2027043998 @default.
- W2913784281 cites W2027418585 @default.
- W2913784281 cites W2029664590 @default.
- W2913784281 cites W2029858131 @default.
- W2913784281 cites W2032531039 @default.
- W2913784281 cites W2033360547 @default.
- W2913784281 cites W2033758025 @default.
- W2913784281 cites W2034279235 @default.
- W2913784281 cites W2036711529 @default.
- W2913784281 cites W2036747476 @default.
- W2913784281 cites W2037736267 @default.
- W2913784281 cites W2038139667 @default.
- W2913784281 cites W2042073539 @default.
- W2913784281 cites W2042461723 @default.
- W2913784281 cites W2042927558 @default.
- W2913784281 cites W2046752196 @default.
- W2913784281 cites W2049622469 @default.
- W2913784281 cites W2054268831 @default.
- W2913784281 cites W2061148690 @default.
- W2913784281 cites W2062577391 @default.
- W2913784281 cites W2062794695 @default.
- W2913784281 cites W2063249692 @default.
- W2913784281 cites W2063686352 @default.
- W2913784281 cites W2064531937 @default.
- W2913784281 cites W2071549499 @default.
- W2913784281 cites W2071843728 @default.
- W2913784281 cites W2073243255 @default.
- W2913784281 cites W2075452125 @default.
- W2913784281 cites W2076103369 @default.
- W2913784281 cites W2076377855 @default.
- W2913784281 cites W2078800870 @default.
- W2913784281 cites W2079318223 @default.
- W2913784281 cites W2079672406 @default.
- W2913784281 cites W2080551472 @default.
- W2913784281 cites W2081009135 @default.
- W2913784281 cites W2082796711 @default.
- W2913784281 cites W2083107399 @default.
- W2913784281 cites W2085342571 @default.
- W2913784281 cites W2087949958 @default.
- W2913784281 cites W2088174145 @default.
- W2913784281 cites W2088228079 @default.
- W2913784281 cites W2088401889 @default.
- W2913784281 cites W2092545077 @default.