Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913784856> ?p ?o ?g. }
- W2913784856 endingPage "1472.e4" @default.
- W2913784856 startingPage "1458" @default.
- W2913784856 abstract "Slit-Robo signaling has been characterized as a repulsive signal for precise axon pathfinding and cell migration during embryonic development. Here, we describe a role for Sox2 in the regulation of Robo1 in Schwann cells and for Slit3-Robo1 signaling in controlling axon guidance within the newly formed nerve bridge following peripheral nerve transection injury. In particular, we show that macrophages form the outermost layer of the nerve bridge and secrete high levels of Slit3, while migratory Schwann cells and fibroblasts inside the nerve bridge express the Robo1 receptor. In line with this pattern of Slit3 and Robo1 expression, we observed multiple axon regeneration and cell migration defects in the nerve bridge of Sox2-, Slit3-, and Robo1-mutant mice. Our findings have revealed important functions for macrophages in the peripheral nervous system, utilizing Slit3-Robo1 signaling to control correct peripheral nerve bridge formation and precise axon targeting to the distal nerve stump following injury." @default.
- W2913784856 created "2019-02-21" @default.
- W2913784856 creator A5018024349 @default.
- W2913784856 creator A5019672254 @default.
- W2913784856 creator A5023316550 @default.
- W2913784856 creator A5036595283 @default.
- W2913784856 creator A5043334666 @default.
- W2913784856 creator A5068403701 @default.
- W2913784856 creator A5080657266 @default.
- W2913784856 creator A5090677105 @default.
- W2913784856 creator A5091737949 @default.
- W2913784856 date "2019-02-01" @default.
- W2913784856 modified "2023-10-14" @default.
- W2913784856 title "RETRACTED: Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge" @default.
- W2913784856 cites W1505616372 @default.
- W2913784856 cites W166440670 @default.
- W2913784856 cites W1784352764 @default.
- W2913784856 cites W1922994157 @default.
- W2913784856 cites W1933245301 @default.
- W2913784856 cites W1935201742 @default.
- W2913784856 cites W1964571549 @default.
- W2913784856 cites W1973501593 @default.
- W2913784856 cites W1974987292 @default.
- W2913784856 cites W1987655927 @default.
- W2913784856 cites W1998510940 @default.
- W2913784856 cites W2005803448 @default.
- W2913784856 cites W2007389030 @default.
- W2913784856 cites W2022908313 @default.
- W2913784856 cites W2034926640 @default.
- W2913784856 cites W2048502950 @default.
- W2913784856 cites W2050935187 @default.
- W2913784856 cites W2052726917 @default.
- W2913784856 cites W2055343760 @default.
- W2913784856 cites W2056574662 @default.
- W2913784856 cites W2058258787 @default.
- W2913784856 cites W2058776356 @default.
- W2913784856 cites W2070381140 @default.
- W2913784856 cites W2086095625 @default.
- W2913784856 cites W2086495566 @default.
- W2913784856 cites W2092173066 @default.
- W2913784856 cites W2093861699 @default.
- W2913784856 cites W2094841924 @default.
- W2913784856 cites W2104086209 @default.
- W2913784856 cites W2107277218 @default.
- W2913784856 cites W2114202894 @default.
- W2913784856 cites W2121764727 @default.
- W2913784856 cites W2148129201 @default.
- W2913784856 cites W2162892919 @default.
- W2913784856 cites W2165287928 @default.
- W2913784856 cites W2169657880 @default.
- W2913784856 cites W2192080449 @default.
- W2913784856 cites W2396814975 @default.
- W2913784856 cites W2410733058 @default.
- W2913784856 cites W2512421145 @default.
- W2913784856 cites W2589145912 @default.
- W2913784856 cites W2591222075 @default.
- W2913784856 cites W2739171987 @default.
- W2913784856 cites W2792461570 @default.
- W2913784856 doi "https://doi.org/10.1016/j.celrep.2018.12.081" @default.
- W2913784856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6367597" @default.
- W2913784856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30726731" @default.
- W2913784856 hasPublicationYear "2019" @default.
- W2913784856 type Work @default.
- W2913784856 sameAs 2913784856 @default.
- W2913784856 citedByCount "61" @default.
- W2913784856 countsByYear W29137848562019 @default.
- W2913784856 countsByYear W29137848562020 @default.
- W2913784856 countsByYear W29137848562021 @default.
- W2913784856 countsByYear W29137848562022 @default.
- W2913784856 countsByYear W29137848562023 @default.
- W2913784856 crossrefType "journal-article" @default.
- W2913784856 hasAuthorship W2913784856A5018024349 @default.
- W2913784856 hasAuthorship W2913784856A5019672254 @default.
- W2913784856 hasAuthorship W2913784856A5023316550 @default.
- W2913784856 hasAuthorship W2913784856A5036595283 @default.
- W2913784856 hasAuthorship W2913784856A5043334666 @default.
- W2913784856 hasAuthorship W2913784856A5068403701 @default.
- W2913784856 hasAuthorship W2913784856A5080657266 @default.
- W2913784856 hasAuthorship W2913784856A5090677105 @default.
- W2913784856 hasAuthorship W2913784856A5091737949 @default.
- W2913784856 hasBestOaLocation W29137848561 @default.
- W2913784856 hasConcept C169760540 @default.
- W2913784856 hasConcept C199215989 @default.
- W2913784856 hasConcept C2777004073 @default.
- W2913784856 hasConcept C2779530196 @default.
- W2913784856 hasConcept C529278444 @default.
- W2913784856 hasConcept C545314008 @default.
- W2913784856 hasConcept C69125201 @default.
- W2913784856 hasConcept C86803240 @default.
- W2913784856 hasConcept C95444343 @default.
- W2913784856 hasConceptScore W2913784856C169760540 @default.
- W2913784856 hasConceptScore W2913784856C199215989 @default.
- W2913784856 hasConceptScore W2913784856C2777004073 @default.
- W2913784856 hasConceptScore W2913784856C2779530196 @default.
- W2913784856 hasConceptScore W2913784856C529278444 @default.
- W2913784856 hasConceptScore W2913784856C545314008 @default.
- W2913784856 hasConceptScore W2913784856C69125201 @default.
- W2913784856 hasConceptScore W2913784856C86803240 @default.