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• W2913790433 abstract "Event Abstract Back to Event Functional connectivity decreases in a rat model of spatial neglect-like deficits Lore Peeters1*, Rukun Hinz1, Changhong Li1 and Georgios A. Keliris1 1 University of Antwerp, Bio-Imaging Lab, Belgium Introduction. Spatial neglect is a frequent consequence of brain damage in humans. It manifests as attentional deficits in perceiving and responding to stimuli in the contralesional space. Despite some evidence of effective treatments in humans, the underlying mechanisms remain largely unknown. Thus, studying a rodent variant of neglect, even if not completely assimilating the condition in humans, can be extremely valuable for a detailed understanding of many of its underlying mechanisms. Aim. Identify functional connectivity changes after inactivation of a central node of the attention/neglect network, i.e. dorsomedial prefrontal cortex (dmPFC), known to cause neglect-like deficits in rats. Methods. Long-Evans rats (N=12) were subjected to a stereotactic surgery in order to lesion the right dmPFC by ibotenic acid injections. Then, the animals were scanned using a 9.4T Biospec MRI scanner. Animals were anesthetized using a S.C. bolus injection of 0.05mg/kg medetomidine followed by an infusion of 0.10mg/kg medetomidine. Brain functional connectivity (FC) was examined at baseline, 1 week post-surgery and 2 weeks post-surgery using resting state functional magnetic resonance imaging (rsfMRI). Results. At 1 week post-surgery, unilateral lesions of the dmPFC caused decreased FC in the attention/neglect network as well as the default-mode like network. Interestingly, FC decreases were also observed in other distinct networks, like the somatosensory network. These decreases were less pronounced at 2 weeks post-surgery, which might indicate FC recovery towards normal baseline levels. Conclusion. The results of this study show FC changes over time following a lesion known to cause neglect-like deficits in rats. Both the FC decrease and FC recovery phase can be identified in this rodent model, supporting its importance to study the human condition. Acknowledgements This research was supported by University Research Fund of University of Antwerp (BOF DOCPRO FFB150340) and by the Fund for Scientific Research Flanders (FWO G048917N). Keywords: Spatial neglect, Attention, rodent models, MRI imaging, resting state functional connectivity Conference: 12th National Congress of the Belgian Society for Neuroscience, Gent, Belgium, 22 May - 22 May, 2017. Presentation Type: Poster Presentation Topic: Disorders of the Nervous System Citation: Peeters L, Hinz R, Li C and Keliris GA (2019). Functional connectivity decreases in a rat model of spatial neglect-like deficits. Front. Neurosci. Conference Abstract: 12th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2017.94.00040 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Miss. Lore Peeters, University of Antwerp, Bio-Imaging Lab, Wilrijk, Antwerp, 2610, Belgium, lore.peeters@uantwerpen.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lore Peeters Rukun Hinz Changhong Li Georgios A Keliris Google Lore Peeters Rukun Hinz Changhong Li Georgios A Keliris Google Scholar Lore Peeters Rukun Hinz Changhong Li Georgios A Keliris PubMed Lore Peeters Rukun Hinz Changhong Li Georgios A Keliris Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2913790433 title "Functional connectivity decreases in a rat model of spatial neglect-like deficits" @default.
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