FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913794705> ?p ?o ?g. }

• W2913794705 endingPage "216" @default.
• W2913794705 startingPage "204" @default.
• W2913794705 abstract "Abstract RN181, a RING finger domain‐containing protein, is an E3 ubiquitin ligase. However, its biological function and clinical significance in cancer biology are obscure. Here, we report that RN181 expression is significantly down‐regulated in 165 tumour tissues of gastric carcinoma (GC) versus adjacent non‐tumour tissues, and inversely associated with tumour differentiation, tumour size, clinical stage, and patient's overall survival. Alterations of RN181 expression in GC cells by retrovirus‐transduced up‐regulation and down‐regulation demonstrated that RN181 functions as a tumour suppressor to inhibit growth of GC in both in vitro culture and in vivo animal models by decreasing tumour cell proliferation and increasing tumour cell apoptosis. Cell cycle analysis revealed that RN181 controls the cell cycle transition from G1 to S phase. Mechanistic studies demonstrated that RN181 inhibits ERK/MAPK signalling, thereby regulating the activity of cyclin D1–CDK4, and consequently controlling progression in the cell cycle from G1 to S phase. Restoring CDK4 in GC cells rescued the inhibitory phenotype produced by RN181 in vitro and in vivo , suggesting a dominant role of CDK4 in control of the tumour growth by RN181. Importantly, RN181 expression is inversely correlated with the expression of cyclin D1 and CDK4 in GC clinical samples, substantiating the role of the RN181–cyclin D1/CDK4 pathway in control of the tumour growth of GC. Our results provide new insights into the pathogenesis and development of GC and rationale for developing novel intervention strategies against GC by disruption of ERK/MAPK–cyclin D1/CDK4 signalling. In addition, RN181 may serve as a novel biomarker for predicting clinical outcome of GC. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland." @default.
• W2913794705 created "2019-02-21" @default.
• W2913794705 creator A5021384155 @default.
• W2913794705 creator A5043311300 @default.
• W2913794705 creator A5043693779 @default.
• W2913794705 creator A5048925301 @default.
• W2913794705 creator A5050664394 @default.
• W2913794705 creator A5057292712 @default.
• W2913794705 creator A5070689473 @default.
• W2913794705 creator A5074952437 @default.
• W2913794705 creator A5074999356 @default.
• W2913794705 creator A5077339153 @default.
• W2913794705 date "2019-04-11" @default.
• W2913794705 modified "2023-10-14" @default.
• W2913794705 title "RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK–cyclin D1/CDK4 pathway" @default.
• W2913794705 cites W1520222296 @default.
• W2913794705 cites W1955052620 @default.
• W2913794705 cites W1975013268 @default.
• W2913794705 cites W1981557521 @default.
• W2913794705 cites W1985213644 @default.
• W2913794705 cites W1997858491 @default.
• W2913794705 cites W2006619267 @default.
• W2913794705 cites W2006656062 @default.
• W2913794705 cites W2019956469 @default.
• W2913794705 cites W2026861859 @default.
• W2913794705 cites W2028186105 @default.
• W2913794705 cites W2035621887 @default.
• W2913794705 cites W2048508614 @default.
• W2913794705 cites W2059755429 @default.
• W2913794705 cites W2073482997 @default.
• W2913794705 cites W2089655089 @default.
• W2913794705 cites W2100439220 @default.
• W2913794705 cites W2101871299 @default.
• W2913794705 cites W2105907922 @default.
• W2913794705 cites W2106198179 @default.
• W2913794705 cites W2107098019 @default.
• W2913794705 cites W2113250638 @default.
• W2913794705 cites W2117692326 @default.
• W2913794705 cites W2124396025 @default.
• W2913794705 cites W2133361872 @default.
• W2913794705 cites W2144114582 @default.
• W2913794705 cites W2146041889 @default.
• W2913794705 cites W2150878386 @default.
• W2913794705 cites W2155429979 @default.
• W2913794705 cites W2155588015 @default.
• W2913794705 cites W2219817965 @default.
• W2913794705 cites W2251541509 @default.
• W2913794705 cites W2272984102 @default.
• W2913794705 cites W2552099557 @default.
• W2913794705 cites W2597872842 @default.
• W2913794705 cites W2917837889 @default.
• W2913794705 doi "https://doi.org/10.1002/path.5246" @default.
• W2913794705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593865" @default.
• W2913794705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30714150" @default.
• W2913794705 hasPublicationYear "2019" @default.
• W2913794705 type Work @default.
• W2913794705 sameAs 2913794705 @default.
• W2913794705 citedByCount "15" @default.
• W2913794705 countsByYear W29137947052020 @default.
• W2913794705 countsByYear W29137947052021 @default.
• W2913794705 countsByYear W29137947052022 @default.
• W2913794705 countsByYear W29137947052023 @default.
• W2913794705 crossrefType "journal-article" @default.
• W2913794705 hasAuthorship W2913794705A5021384155 @default.
• W2913794705 hasAuthorship W2913794705A5043311300 @default.
• W2913794705 hasAuthorship W2913794705A5043693779 @default.
• W2913794705 hasAuthorship W2913794705A5048925301 @default.
• W2913794705 hasAuthorship W2913794705A5050664394 @default.
• W2913794705 hasAuthorship W2913794705A5057292712 @default.
• W2913794705 hasAuthorship W2913794705A5070689473 @default.
• W2913794705 hasAuthorship W2913794705A5074952437 @default.
• W2913794705 hasAuthorship W2913794705A5074999356 @default.
• W2913794705 hasAuthorship W2913794705A5077339153 @default.
• W2913794705 hasBestOaLocation W29137947051 @default.
• W2913794705 hasConcept C104317684 @default.
• W2913794705 hasConcept C11882975 @default.
• W2913794705 hasConcept C121608353 @default.
• W2913794705 hasConcept C134459356 @default.
• W2913794705 hasConcept C16438837 @default.
• W2913794705 hasConcept C184235292 @default.
• W2913794705 hasConcept C199835354 @default.
• W2913794705 hasConcept C25602115 @default.
• W2913794705 hasConcept C28179978 @default.
• W2913794705 hasConcept C29537977 @default.
• W2913794705 hasConcept C502942594 @default.
• W2913794705 hasConcept C54355233 @default.
• W2913794705 hasConcept C57074206 @default.
• W2913794705 hasConcept C62112901 @default.
• W2913794705 hasConcept C86803240 @default.
• W2913794705 hasConcept C95444343 @default.
• W2913794705 hasConceptScore W2913794705C104317684 @default.
• W2913794705 hasConceptScore W2913794705C11882975 @default.
• W2913794705 hasConceptScore W2913794705C121608353 @default.
• W2913794705 hasConceptScore W2913794705C134459356 @default.
• W2913794705 hasConceptScore W2913794705C16438837 @default.
• W2913794705 hasConceptScore W2913794705C184235292 @default.
• W2913794705 hasConceptScore W2913794705C199835354 @default.
• W2913794705 hasConceptScore W2913794705C25602115 @default.

• next