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- W2913802353 abstract "Abstract Nearly 6 decades ago, Lewis Wolpert proposed the relaxation of the polar cell cortex by the radial arrays of astral microtubules as a mechanism for cleavage furrow induction (White and Borisy, 1983; Wolpert, 1960). While this mechanism has remained controversial (Rappaport, 1996), recent work has provided evidence for polar relaxation by astral microtubules (Chen et al., 2008; Dechant and Glotzer, 2003; Foe and Dassow, 2008; Murthy and Wadsworth, 2008; Werner et al., 2007), although its molecular mechanisms remain elusive. Here, using C. elegans embryos, we show that polar relaxation is achieved through dynein-mediated removal of myosin II from the polar cortexes. Mutants that position centrosomes closer to the polar cortex accelerated furrow induction whereas suppression of dynein activity delayed furrowing. We provide evidence that dynein-mediated removal of myosin II from the polar cortexes triggers cortical flow towards the cell equator, which induces the assembly of the actomyosin contractile ring. These studies for the first time provide a molecular basis for the aster-dependent polar relaxation, which works in parallel with equatorial stimulation to promote robust cytokinesis." @default.
- W2913802353 created "2019-02-21" @default.
- W2913802353 creator A5003968449 @default.
- W2913802353 creator A5015705751 @default.
- W2913802353 creator A5057876000 @default.
- W2913802353 creator A5058125442 @default.
- W2913802353 creator A5078769065 @default.
- W2913802353 date "2019-02-16" @default.
- W2913802353 modified "2023-09-23" @default.
- W2913802353 title "Polar relaxation by dynein-mediated removal of cortical myosin II" @default.
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