FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913813679> ?p ?o ?g. }

• W2913813679 endingPage "357" @default.
• W2913813679 startingPage "347" @default.
• W2913813679 abstract "Spinal cord injury results in sensation dysfunction. This study explored miR-142-3p, which acts a critical role in sciatic nerve conditioning injury (SNCI) promoting the repair of the dorsal column injury and validated its function on primary sensory neuron(DRG). miR-142-3p expression increased greatly in the spinal cord dorsal column lesion (SDCL) group and increased slightly in the SNCI group. Subsequently, the expression of adenylate cyclase 9 (AC9), the target gene of miR-142-3p, declined sharply in the SDCL group and declined limitedly in the SNCI group. The expression trend of cAMP was opposite to that of miR-142-3p. MiR-142-3p inhibitor improved the axon length, upregulated the expression of AC9, cAMP, p-CREB, IL-6, and GAP43, and downregulated the expression of GTP-RhoA. miR-142-3p inhibitor combined with AC9 siRNA showed shorter axon length, the expression of AC9, cAMP, p-CREB, IL-6, and GAP43 was decreased, and the expression of GTP-RhoA was increased. H89 and AG490, inhibitors of cAMP/PKA pathway and IL6/STAT3/GAP43 axis, respectively, declined the enhanced axonal growth by miR-142-3p inhibitor and altered the expression level of the corresponding proteins. Thus, a substitution therapy using Sorafenib that downregulates the miR-142-3p expression for SNCI was investigated. The results showed the effect of Sorafenib was similar to that of miR-142-3p inhibitor and SNCI on both axon growth in vitro and sensory conduction function recovery in vivo. In conclusion, miR-142-3p acts a pivotal role in SNCI promoting the repair of dorsal column injury. Sorafenib mimics the treatment effect of SNCI via downregulation of miR-142-3p, subsequently, promoting sensory conduction function recovery post dorsal column injury." @default.
• W2913813679 created "2019-02-21" @default.
• W2913813679 creator A5006822602 @default.
• W2913813679 creator A5015431603 @default.
• W2913813679 creator A5022391567 @default.
• W2913813679 creator A5028960850 @default.
• W2913813679 creator A5032710452 @default.
• W2913813679 creator A5034995105 @default.
• W2913813679 creator A5036777587 @default.
• W2913813679 creator A5051149614 @default.
• W2913813679 creator A5054065981 @default.
• W2913813679 creator A5056101043 @default.
• W2913813679 creator A5063835503 @default.
• W2913813679 creator A5066576453 @default.
• W2913813679 creator A5066599847 @default.
• W2913813679 creator A5081945380 @default.
• W2913813679 creator A5082365446 @default.
• W2913813679 creator A5086078254 @default.
• W2913813679 creator A5088888083 @default.
• W2913813679 date "2019-04-01" @default.
• W2913813679 modified "2023-10-13" @default.
• W2913813679 title "Sorafenib promotes sensory conduction function recovery via miR-142-3p/AC9/cAMP axis post dorsal column injury" @default.
• W2913813679 cites W1781091308 @default.
• W2913813679 cites W1876125759 @default.
• W2913813679 cites W1938371914 @default.
• W2913813679 cites W1950473859 @default.
• W2913813679 cites W1973345051 @default.
• W2913813679 cites W1988517763 @default.
• W2913813679 cites W2017797144 @default.
• W2913813679 cites W2019111371 @default.
• W2913813679 cites W2030812672 @default.
• W2913813679 cites W2031656086 @default.
• W2913813679 cites W2034580378 @default.
• W2913813679 cites W2040955471 @default.
• W2913813679 cites W2041229780 @default.
• W2913813679 cites W2045165874 @default.
• W2913813679 cites W2048837011 @default.
• W2913813679 cites W2049893910 @default.
• W2913813679 cites W2057838550 @default.
• W2913813679 cites W2061194293 @default.
• W2913813679 cites W2072048515 @default.
• W2913813679 cites W2093147111 @default.
• W2913813679 cites W2112905324 @default.
• W2913813679 cites W2113697023 @default.
• W2913813679 cites W2127202058 @default.
• W2913813679 cites W2164406367 @default.
• W2913813679 cites W2193607675 @default.
• W2913813679 cites W2283008781 @default.
• W2913813679 cites W2326765929 @default.
• W2913813679 cites W2470695684 @default.
• W2913813679 cites W2485306255 @default.
• W2913813679 cites W2570761635 @default.
• W2913813679 cites W2726753871 @default.
• W2913813679 cites W2733403937 @default.
• W2913813679 cites W2752868583 @default.
• W2913813679 cites W2791298525 @default.
• W2913813679 cites W2794802936 @default.
• W2913813679 cites W2891917070 @default.
• W2913813679 cites W2901393337 @default.
• W2913813679 doi "https://doi.org/10.1016/j.neuropharm.2019.01.031" @default.
• W2913813679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30710569" @default.
• W2913813679 hasPublicationYear "2019" @default.
• W2913813679 type Work @default.
• W2913813679 sameAs 2913813679 @default.
• W2913813679 citedByCount "14" @default.
• W2913813679 countsByYear W29138136792019 @default.
• W2913813679 countsByYear W29138136792020 @default.
• W2913813679 countsByYear W29138136792021 @default.
• W2913813679 countsByYear W29138136792022 @default.
• W2913813679 countsByYear W29138136792023 @default.
• W2913813679 crossrefType "journal-article" @default.
• W2913813679 hasAuthorship W2913813679A5006822602 @default.
• W2913813679 hasAuthorship W2913813679A5015431603 @default.
• W2913813679 hasAuthorship W2913813679A5022391567 @default.
• W2913813679 hasAuthorship W2913813679A5028960850 @default.
• W2913813679 hasAuthorship W2913813679A5032710452 @default.
• W2913813679 hasAuthorship W2913813679A5034995105 @default.
• W2913813679 hasAuthorship W2913813679A5036777587 @default.
• W2913813679 hasAuthorship W2913813679A5051149614 @default.
• W2913813679 hasAuthorship W2913813679A5054065981 @default.
• W2913813679 hasAuthorship W2913813679A5056101043 @default.
• W2913813679 hasAuthorship W2913813679A5063835503 @default.
• W2913813679 hasAuthorship W2913813679A5066576453 @default.
• W2913813679 hasAuthorship W2913813679A5066599847 @default.
• W2913813679 hasAuthorship W2913813679A5081945380 @default.
• W2913813679 hasAuthorship W2913813679A5082365446 @default.
• W2913813679 hasAuthorship W2913813679A5086078254 @default.
• W2913813679 hasAuthorship W2913813679A5088888083 @default.
• W2913813679 hasConcept C104317684 @default.
• W2913813679 hasConcept C113246987 @default.
• W2913813679 hasConcept C126322002 @default.
• W2913813679 hasConcept C134018914 @default.
• W2913813679 hasConcept C1629964 @default.
• W2913813679 hasConcept C169760540 @default.
• W2913813679 hasConcept C202751555 @default.
• W2913813679 hasConcept C204232928 @default.
• W2913813679 hasConcept C2775991916 @default.
• W2913813679 hasConcept C2776281502 @default.

• next