Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913826244> ?p ?o ?g. }
- W2913826244 endingPage "6352" @default.
- W2913826244 startingPage "6344" @default.
- W2913826244 abstract "Stress granules (SGs) are cytoplasmic RNA-protein aggregates formed in response to inhibition of translation initiation. SGs contribute to the stress response and are implicated in a variety of diseases, including cancer and some forms of neurodegeneration. Neurodegenerative diseases often involve chronic phosphorylation of eukaryotic initiation factor 2α (eIF2α), with deletions of eIF2α kinases or treatment with eIF2α kinase inhibitors being protective in some animal models of disease. However, how and why the integrated stress response (ISR) is activated in different forms of neurodegeneration remains unclear. Because neuroinflammation is common to many neurodegenerative diseases, we hypothesized that inflammatory factors contribute to ISR activation in a cell-nonautonomous manner. Using fluorescence microscopy and immunoblotting, we show here that the endogenously produced product of inflammation, 15-deoxy-Δ12,14-prostaglandin J2 (15-d-PGJ2), triggers eIF2α phosphorylation, thereby activating the ISR, repressing bulk translation, and triggering SG formation. Our findings define a mechanism by which inflammation activates the ISR in a cell-nonautonomous manner and suggest that inhibition of 15-d-PGJ2 production might be a useful therapeutic strategy in some neuroinflammatory contexts." @default.
- W2913826244 created "2019-02-21" @default.
- W2913826244 creator A5014796446 @default.
- W2913826244 creator A5016800388 @default.
- W2913826244 date "2019-04-01" @default.
- W2913826244 modified "2023-10-11" @default.
- W2913826244 title "15-Deoxy-Δ12,14-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2α and activates the integrated stress response" @default.
- W2913826244 cites W1970195253 @default.
- W2913826244 cites W1975167087 @default.
- W2913826244 cites W1998731673 @default.
- W2913826244 cites W2007400675 @default.
- W2913826244 cites W2030194678 @default.
- W2913826244 cites W2042706422 @default.
- W2913826244 cites W2044566850 @default.
- W2913826244 cites W2044821390 @default.
- W2913826244 cites W2046454316 @default.
- W2913826244 cites W2046892501 @default.
- W2913826244 cites W2050071796 @default.
- W2913826244 cites W2057249855 @default.
- W2913826244 cites W2058333349 @default.
- W2913826244 cites W2059355164 @default.
- W2913826244 cites W2062446483 @default.
- W2913826244 cites W2067040999 @default.
- W2913826244 cites W2072281823 @default.
- W2913826244 cites W2073571863 @default.
- W2913826244 cites W2079644509 @default.
- W2913826244 cites W2083651501 @default.
- W2913826244 cites W2085622324 @default.
- W2913826244 cites W2094118946 @default.
- W2913826244 cites W2097367691 @default.
- W2913826244 cites W2106758408 @default.
- W2913826244 cites W2109652338 @default.
- W2913826244 cites W2115637560 @default.
- W2913826244 cites W2126238233 @default.
- W2913826244 cites W2141934884 @default.
- W2913826244 cites W2150356698 @default.
- W2913826244 cites W2167500696 @default.
- W2913826244 cites W2233830471 @default.
- W2913826244 cites W2409283684 @default.
- W2913826244 cites W2566818766 @default.
- W2913826244 cites W2735295607 @default.
- W2913826244 cites W2773477944 @default.
- W2913826244 cites W2775790403 @default.
- W2913826244 cites W2784970793 @default.
- W2913826244 cites W2792571530 @default.
- W2913826244 cites W2801346997 @default.
- W2913826244 doi "https://doi.org/10.1074/jbc.ra118.007138" @default.
- W2913826244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6484127" @default.
- W2913826244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30723157" @default.
- W2913826244 hasPublicationYear "2019" @default.
- W2913826244 type Work @default.
- W2913826244 sameAs 2913826244 @default.
- W2913826244 citedByCount "18" @default.
- W2913826244 countsByYear W29138262442019 @default.
- W2913826244 countsByYear W29138262442020 @default.
- W2913826244 countsByYear W29138262442021 @default.
- W2913826244 countsByYear W29138262442022 @default.
- W2913826244 countsByYear W29138262442023 @default.
- W2913826244 crossrefType "journal-article" @default.
- W2913826244 hasAuthorship W2913826244A5014796446 @default.
- W2913826244 hasAuthorship W2913826244A5016800388 @default.
- W2913826244 hasBestOaLocation W29138262441 @default.
- W2913826244 hasConcept C104317684 @default.
- W2913826244 hasConcept C105580179 @default.
- W2913826244 hasConcept C117838200 @default.
- W2913826244 hasConcept C11960822 @default.
- W2913826244 hasConcept C126322002 @default.
- W2913826244 hasConcept C149364088 @default.
- W2913826244 hasConcept C184235292 @default.
- W2913826244 hasConcept C203014093 @default.
- W2913826244 hasConcept C2776914184 @default.
- W2913826244 hasConcept C2776925932 @default.
- W2913826244 hasConcept C2779134260 @default.
- W2913826244 hasConcept C2779638656 @default.
- W2913826244 hasConcept C2780096491 @default.
- W2913826244 hasConcept C4718897 @default.
- W2913826244 hasConcept C55493867 @default.
- W2913826244 hasConcept C71924100 @default.
- W2913826244 hasConcept C78604142 @default.
- W2913826244 hasConcept C86803240 @default.
- W2913826244 hasConcept C87753298 @default.
- W2913826244 hasConcept C93734116 @default.
- W2913826244 hasConcept C95444343 @default.
- W2913826244 hasConcept C97154109 @default.
- W2913826244 hasConceptScore W2913826244C104317684 @default.
- W2913826244 hasConceptScore W2913826244C105580179 @default.
- W2913826244 hasConceptScore W2913826244C117838200 @default.
- W2913826244 hasConceptScore W2913826244C11960822 @default.
- W2913826244 hasConceptScore W2913826244C126322002 @default.
- W2913826244 hasConceptScore W2913826244C149364088 @default.
- W2913826244 hasConceptScore W2913826244C184235292 @default.
- W2913826244 hasConceptScore W2913826244C203014093 @default.
- W2913826244 hasConceptScore W2913826244C2776914184 @default.
- W2913826244 hasConceptScore W2913826244C2776925932 @default.
- W2913826244 hasConceptScore W2913826244C2779134260 @default.
- W2913826244 hasConceptScore W2913826244C2779638656 @default.
- W2913826244 hasConceptScore W2913826244C2780096491 @default.
- W2913826244 hasConceptScore W2913826244C4718897 @default.