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• W2913851008 abstract "The co-occurrence of Parkinson's disease (PD) in association with Multiple Sclerosis (MS) has been reported occasionally [ [1] Valkovic P. Krastev G. Mako M. Leitner P. Gasser T. A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis. Movement disorders: Off. J. Move. Dis. Soc. 2007; 22: 2278-2281 Crossref PubMed Scopus (14) Google Scholar , [2] Pedemonte E. Trabucco E. Cella M. Solaro C. Parkinsonism in multiple sclerosis patients: a casual or causal association?. Park. Relat. Disord. 2013; 19: 492-493 Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar ] (see Table 1). As advanced age is one of the few risk factors for PD, with longer life expectancy MS patients could be at risk of developing PD [ [3] Nielsen N.M. Pasternak B. Stenager E. Koch-Henriksen N. Frisch M. Multiple sclerosis and risk of Parkinson's disease: a Danish nationwide cohort study. Eur. J. Neurol.: Off. J. Europ. Fed. Neurol. Soc. 2014; 21: 107-111 Crossref PubMed Scopus (14) Google Scholar ]. We report clinic-pathologic findings in a PD patient with atypical clinical features in whom co-existing demyelinating lesions were detected at postmortem evaluation. Table 1Literature overview of co-incident PD and MS. Reference n Diagnosis (P/L)* Age of PD/PS onset NP Hypothesis PD/PS diagnosis based on Response to MS/PD treatment Pedemonte et al. 7 MS/PS 39-73y** no coincidental DAT scan only levodopa response was described Damasio et al. [ [6] Damasio J. Ramos C. Valdemar L. da Silva A.M. Magalhães M. Coincidental case of young-onset Parkinson disease and multiple sclerosis. Neurol. 2011; : 286-288 Google Scholar ] 1 MS/PD 38y no coincidental DAT scan no Valdovic et al. 1 PD/MS 36y no coincidental DAT scan no Etemadifar et al. [ [7] Etemadifar M. Afshar F. Nasr Z. Kheradnabd M. Parkinsonism associated with multiple sclerosis: a report of eight new cases and a review on the literature. Iran. J. Neurol. 2014; : 88-93 Google Scholar ] 8 MS/PD 30-55*** no coincidental clinical symptoms unknown Barum et al. [ [8] Barum B. Brinar V.V. Zadro I. Lusic I. Radovic D. Habek M. Parkinsonism and multiple sclerosis- is there association?. Clin. Neurol. Neurosurg. 2008; : 958-961 Google Scholar ] 2 MS/PD 39, 56 no coincidental DAT scan good response to corticosteroid and levodopa * P- presenting symptoms; l-late symptoms; **ages: 39y, 56y, 63y, 71y,73y; **ages: 30y,31y,39y, 43y, 44y, 55y. PS- Parkinsonian syndrome; PD- Parkinson's disease; NP- Neuropathological evaluation; DAT scan-dopamine transporters scan. Open table in a new tab * P- presenting symptoms; l-late symptoms; **ages: 39y, 56y, 63y, 71y,73y; **ages: 30y,31y,39y, 43y, 44y, 55y. PS- Parkinsonian syndrome; PD- Parkinson's disease; NP- Neuropathological evaluation; DAT scan-dopamine transporters scan." @default.
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• W2913851008 date "2019-05-01" @default.
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• W2913851008 title "Co-morbid demyelinating lesions and atypical clinical features in a patient with Parkinson's disease" @default.
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• W2913851008 doi "https://doi.org/10.1016/j.parkreldis.2019.01.015" @default.
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