Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913852059> ?p ?o ?g. }
- W2913852059 endingPage "86" @default.
- W2913852059 startingPage "70" @default.
- W2913852059 abstract "SUMMARY The prevalence of type 2 diabetes mellitus (T2DM) in the elderly grew sharply over the last decade. Reduced insulin sensitivity and secretory capacity, weight gain, sarcopenia, and elevated adiposity are all common metabolic and body changes in the aging population that favor an increased risk of hypoglycemia, frailty syndrome, falls, and cognitive dysfunction. First line antidiabetic therapy is frequently not safe in older individuals because of its high risk of hypoglycemia and prevalent co-morbid diseases, such as chronic kidney disease, osteoporosis, cardiovascular disease, and obesity. Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a new class of antidiabetic therapy that inhibits glucose and sodium reabsorption on renal proximal convoluted tubule. Its effect is well demonstrated in various clinical scenarios in the younger population. This review and metanalysis describe particularities of the SGLT2i on the elderly, with mechanistic insights of the potential benefit and remaining challenges about the use of these drugs in this important age group. Further, we will present a meta-analysis of the main effects of SGLT2i reported in post-hoc studies in which the median age of the subgroups analyzed was over 60 years. Despite the absence of specific clinical trials for this population, our findings suggest that SGLT2i therapy on older individuals is effective to lower glucose and maintain its effect on systolic blood pressure and body weight." @default.
- W2913852059 created "2019-02-21" @default.
- W2913852059 creator A5000704932 @default.
- W2913852059 creator A5003436657 @default.
- W2913852059 creator A5064295057 @default.
- W2913852059 creator A5069050485 @default.
- W2913852059 creator A5070288162 @default.
- W2913852059 creator A5080033793 @default.
- W2913852059 creator A5087574187 @default.
- W2913852059 date "2019-01-01" @default.
- W2913852059 modified "2023-10-01" @default.
- W2913852059 title "Inhibition of the sodium-glucose co-transporter 2 in the elderly: clinical and mechanistic insights into safety and efficacy" @default.
- W2913852059 cites W1574738033 @default.
- W2913852059 cites W1595211679 @default.
- W2913852059 cites W1718902802 @default.
- W2913852059 cites W1820387888 @default.
- W2913852059 cites W1834962231 @default.
- W2913852059 cites W1916092690 @default.
- W2913852059 cites W1920830047 @default.
- W2913852059 cites W1943654307 @default.
- W2913852059 cites W1953794210 @default.
- W2913852059 cites W1955935325 @default.
- W2913852059 cites W1964402404 @default.
- W2913852059 cites W1972124610 @default.
- W2913852059 cites W1973594078 @default.
- W2913852059 cites W1986019364 @default.
- W2913852059 cites W1986074152 @default.
- W2913852059 cites W1987553321 @default.
- W2913852059 cites W1989229815 @default.
- W2913852059 cites W1990025047 @default.
- W2913852059 cites W1996141009 @default.
- W2913852059 cites W1996837305 @default.
- W2913852059 cites W2001294418 @default.
- W2913852059 cites W2003346248 @default.
- W2913852059 cites W2007248715 @default.
- W2913852059 cites W2008577165 @default.
- W2913852059 cites W2010055261 @default.
- W2913852059 cites W2011753046 @default.
- W2913852059 cites W2012245085 @default.
- W2913852059 cites W2012901264 @default.
- W2913852059 cites W2019285763 @default.
- W2913852059 cites W2019807551 @default.
- W2913852059 cites W2021517048 @default.
- W2913852059 cites W2024878386 @default.
- W2913852059 cites W2024986996 @default.
- W2913852059 cites W2026271802 @default.
- W2913852059 cites W2026412750 @default.
- W2913852059 cites W2029674944 @default.
- W2913852059 cites W2030192134 @default.
- W2913852059 cites W2031730303 @default.
- W2913852059 cites W2033485810 @default.
- W2913852059 cites W2035894485 @default.
- W2913852059 cites W2038348179 @default.
- W2913852059 cites W2038880256 @default.
- W2913852059 cites W2041107146 @default.
- W2913852059 cites W2042850859 @default.
- W2913852059 cites W2043428857 @default.
- W2913852059 cites W2044102028 @default.
- W2913852059 cites W2044904729 @default.
- W2913852059 cites W2045790951 @default.
- W2913852059 cites W2046168827 @default.
- W2913852059 cites W2046418188 @default.
- W2913852059 cites W2050608615 @default.
- W2913852059 cites W2051865087 @default.
- W2913852059 cites W2052526874 @default.
- W2913852059 cites W2054361323 @default.
- W2913852059 cites W2059897304 @default.
- W2913852059 cites W2060030405 @default.
- W2913852059 cites W2060832805 @default.
- W2913852059 cites W2062236701 @default.
- W2913852059 cites W2062930842 @default.
- W2913852059 cites W2070572867 @default.
- W2913852059 cites W2072185022 @default.
- W2913852059 cites W2076506641 @default.
- W2913852059 cites W2076686606 @default.
- W2913852059 cites W2077038286 @default.
- W2913852059 cites W2077636750 @default.
- W2913852059 cites W2080383778 @default.
- W2913852059 cites W2083485319 @default.
- W2913852059 cites W2087271865 @default.
- W2913852059 cites W2088148829 @default.
- W2913852059 cites W2088692910 @default.
- W2913852059 cites W2093324206 @default.
- W2913852059 cites W2096592656 @default.
- W2913852059 cites W2097224352 @default.
- W2913852059 cites W2097870088 @default.
- W2913852059 cites W2099281324 @default.
- W2913852059 cites W2100796772 @default.
- W2913852059 cites W2101329765 @default.
- W2913852059 cites W2103649881 @default.
- W2913852059 cites W2103771935 @default.
- W2913852059 cites W2110067540 @default.
- W2913852059 cites W2110140798 @default.
- W2913852059 cites W2112834655 @default.
- W2913852059 cites W2113087113 @default.
- W2913852059 cites W2116974726 @default.
- W2913852059 cites W2117470164 @default.
- W2913852059 cites W2118125504 @default.