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- W2913869635 abstract "Type C hepatitis is caused by the hepatitis C virus (HCV), and is a prevalent global health problem. Hepatitis C is a hepatotrophic RNA virus. An estimated 170 million people are infected with the virus. Hepatitis C virus may cause asymptomatic acute infections, and chronic hepatitis leading to cirrhosis and hepatocellular carcinoma. Six major genotypes of the virus are recognized. Epidemiological, viral and host factors have been associated with differences in HCV clearance or persistence, and studies have demonstrated that a strong host immune response against HCV favours viral clearance. Genetic variation in the immune response may contribute to the ability to clear the virus. The current standard of care for hepatitis C is pegylated interferon (PEG IFN) used in combination with ribavirin (RBV). Each genotype responds differently to treatment. A single nucleotide polymorphism upstream of the IL28B gene, which encodes the type III IFN, IFN-λ3, associates strongly with response to IFN treatment. More effective, direct antiviral therapies are being developed." @default.
- W2913869635 created "2019-02-21" @default.
- W2913869635 creator A5043416638 @default.
- W2913869635 creator A5080765883 @default.
- W2913869635 date "2011-04-25" @default.
- W2913869635 modified "2023-10-18" @default.
- W2913869635 title "Hepatitis C" @default.
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- W2913869635 doi "https://doi.org/10.1002/9781444341294.ch20" @default.
- W2913869635 hasPublicationYear "2011" @default.
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