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- W2913873296 abstract "The ApoE#epsilon#4 heterozygous (+/-) transgenic mice were bred to mice homozygous (+/+) for double mutants amyloid precursor protein (APPV717F) transgene to develop the bigenic mice with age-dependent AD neuropathology. The integration of the transgenes was identified by PCR and Soutyern blot hybridization. Six bigenic mice were identified among 23 newborn mice. This animal model can be used to study the pathogenesis of AD and to investigate the role of ApoE in Alzheimer's disease." @default.
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- W2913873296 date "2005-01-01" @default.
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- W2913873296 title "Generation of bigenic transgenic mice carrying human {sl ApoE}#epsilon#4 and mutant {sl APP} gene" @default.
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