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- W2913881106 abstract "Summary Tissue morphogenesis is strikingly reproducible. Yet, how tissues are robustly sculpted, even under challenging conditions, is unknown. Here, we combined network analysis, experimental perturbations, and computational modeling to determine how network connectivity between hundreds of contractile cells on the ventral side of the Drosophila embryo ensures robust tissue folding. We identified two network properties that mechanically promote robustness. First, redundant supracellular cytoskeletal network paths ensure global connectivity, even with network degradation. By forming many more connections than are required, morphogenesis is not disrupted by local network damage, analogous to the way redundancy guarantees the large-scale function of vasculature and transportation networks. Second, directional stiffening of edges oriented orthogonal to the folding axis promotes furrow formation at lower contractility levels. Structural redundancy and directional network stiffening ensure robust tissue folding with proper orientation." @default.
- W2913881106 created "2019-02-21" @default.
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- W2913881106 date "2019-02-07" @default.
- W2913881106 modified "2023-09-26" @default.
- W2913881106 title "Structural redundancy in supracellular actomyosin networks enables robust tissue folding" @default.
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- W2913881106 doi "https://doi.org/10.1101/530816" @default.
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