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• W2913883320 endingPage "196" @default.
• W2913883320 startingPage "186" @default.
• W2913883320 abstract "Tissue-resident memory CD8+ T cells (TRM) are a lymphocyte subpopulation that is retained in non-lymphoid tissues. They do not recirculate and are phenotypically and functionally distinct from central memory and effector memory T cells (TCM and TEM). Hepatic TRM are generated by multiple candidate malaria vaccination strategies, likely after delivery of antigen to the liver. Hyper vigilant hepatic TRM are capable of scanning for infected hepatocytes and rapidly producing IFN-γ and other proinflammatory cytokines in response to P. falciparum-infected hepatocytes. Local IFN-γ production potentially represents an important immune effector function, arresting the development of Plasmodium liver stages. After P. falciparum sporozoite immunization, hepatic TRM may represent a first line of defense suppressing infection locally but also recruiting other effector cells to the liver. Recently, a population of non-recirculating, tissue-resident memory CD8+ T cells has been identified; cells that seems to act as key sentinels for invading microorganisms with enhanced effector functions. In malaria, the liver represents the first site for parasite development before a definite infection is established in circulating red blood cells. Here, we discuss the evidence obtained from animal models on several diseases and hypothesize that liver-resident memory CD8+ T cells (hepatic TRM) play a critical role in providing protective liver-stage immunity against Plasmodium malaria parasites. Although observations in human malaria trials are limited to peripheral blood, we propose recommendations for the translation of some of these findings to human malaria research. Recently, a population of non-recirculating, tissue-resident memory CD8+ T cells has been identified; cells that seems to act as key sentinels for invading microorganisms with enhanced effector functions. In malaria, the liver represents the first site for parasite development before a definite infection is established in circulating red blood cells. Here, we discuss the evidence obtained from animal models on several diseases and hypothesize that liver-resident memory CD8+ T cells (hepatic TRM) play a critical role in providing protective liver-stage immunity against Plasmodium malaria parasites. Although observations in human malaria trials are limited to peripheral blood, we propose recommendations for the translation of some of these findings to human malaria research. transfer of antigen-experienced T cells isolated from one mouse into another antigen-naïve mouse. antigen-experienced T cells that can home to secondary lymphoid organs, characterized by expression of CD45RO, CD62L, and CCR7 in humans. antigen-experienced T cells that circulate in the peripheral blood, characterized by expression of CD45RO and a lack of CD62L and CCR7 expression in humans. main parenchymal tissue of the liver and the cell type infected by Plasmodium parasites of the sporozoite stage. mononuclear phagocytes located in the walls of liver sinusoids. endothelial cells that line the liver sinusoids; gaps between these cells allow for contact between immune cells in the sinusoids and the liver parenchyma. capillary vessels unique to the liver where blood from the hepatic artery and portal vein mixes; characterized by a reduced speed of blood flow and a fenestrated endothelium. T cells that have not been stimulated by their cognate antigen, characterized by expression of CD45RA, CD62L, and CCR7. the circulatory systems of two mice or rats are surgically linked, thereby allowing for the continuous exchange of peripheral blood. the first stage of the malaria parasite life cycle in humans, injected into the skin by a feeding, infected Anopheles mosquito. protection against the pre-erythrocytic stages of Plasmodium, either against sporozoite or liver stages, preventing the onset of blood stage infection. after multiple rounds of cell division, CD8+ T cells lose proliferative potential and become increasingly sensitive to cell death. antigen-experienced T cells that home to non-lymphoid tissues and do not recirculate, characterized by the expression of CD69." @default.
• W2913883320 created "2019-02-21" @default.
• W2913883320 creator A5008109254 @default.
• W2913883320 creator A5041560319 @default.
• W2913883320 creator A5073424910 @default.
• W2913883320 date "2019-03-01" @default.
• W2913883320 modified "2023-09-25" @default.
• W2913883320 title "Can Patrolling Liver-Resident T Cells Control Human Malaria Parasite Development?" @default.
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