FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913883970> ?p ?o ?g. }

• W2913883970 abstract "The prion hypothesis states that misfolded proteins can act as infectious agents that trigger the misfolding and aggregation of healthy proteins to transmit a variety of neurodegenerative diseases. Increasing evidence suggests that pathogenic proteins in Alzheimer’s disease adapt prion-like mechanisms and spread across the brain along an anatomically connected network. Local kinetics models of protein misfolding and global network models of protein diffusion provide valuable insight into the dynamics of prion-like diseases. Yet, to date, these models have not been combined to simulate how pathological proteins multiply and spread across the human brain. Here we model the prion-like spreading of Alzheimer’s disease by combining misfolding kinetics and network diffusion through a connectivity-weighted Laplacian graph created from 418 brains of the Human Connectome Project. The nodes of the graph represent anatomic regions of interest and the edges represent their con-nectivity, weighted by the mean fiber number divided by the mean fiber length. We show that our brain network model correctly predicts the neuropathological pattern of Alzheimer’s disease and captures the key characteristic features of whole brain models at a fraction of their computational cost. To illustrate the potential of brain network modeling in neurodegeneration, we simulate biomarker curves, infection times, and two promising therapeutic strategies to delay the onset of neurodegeneration: reduced production and increased clearance of misfolded protein." @default.
• W2913883970 created "2019-02-21" @default.
• W2913883970 creator A5004854940 @default.
• W2913883970 creator A5007417082 @default.
• W2913883970 creator A5010409175 @default.
• W2913883970 creator A5069976865 @default.
• W2913883970 creator A5089205791 @default.
• W2913883970 date "2019-01-24" @default.
• W2913883970 modified "2023-10-18" @default.
• W2913883970 title "Prion-like spreading of Alzheimer’s disease within the brain’s connectome" @default.
• W2913883970 cites W1897859562 @default.
• W2913883970 cites W1965715402 @default.
• W2913883970 cites W1978514520 @default.
• W2913883970 cites W1979426401 @default.
• W2913883970 cites W1999653836 @default.
• W2913883970 cites W2009531026 @default.
• W2913883970 cites W2016787780 @default.
• W2913883970 cites W2018852249 @default.
• W2913883970 cites W2034147064 @default.
• W2913883970 cites W2052742260 @default.
• W2913883970 cites W2053838094 @default.
• W2913883970 cites W2076220672 @default.
• W2913883970 cites W2079949023 @default.
• W2913883970 cites W2089691915 @default.
• W2913883970 cites W2094881767 @default.
• W2913883970 cites W2156606243 @default.
• W2913883970 cites W2286126108 @default.
• W2913883970 cites W2324660492 @default.
• W2913883970 cites W2511999769 @default.
• W2913883970 cites W2512562388 @default.
• W2913883970 cites W2772202429 @default.
• W2913883970 cites W2796022617 @default.
• W2913883970 cites W2808028315 @default.
• W2913883970 cites W2897675393 @default.
• W2913883970 doi "https://doi.org/10.1101/529438" @default.
• W2913883970 hasPublicationYear "2019" @default.
• W2913883970 type Work @default.
• W2913883970 sameAs 2913883970 @default.
• W2913883970 citedByCount "8" @default.
• W2913883970 countsByYear W29138839702019 @default.
• W2913883970 countsByYear W29138839702020 @default.
• W2913883970 countsByYear W29138839702021 @default.
• W2913883970 countsByYear W29138839702022 @default.
• W2913883970 countsByYear W29138839702023 @default.
• W2913883970 crossrefType "posted-content" @default.
• W2913883970 hasAuthorship W2913883970A5004854940 @default.
• W2913883970 hasAuthorship W2913883970A5007417082 @default.
• W2913883970 hasAuthorship W2913883970A5010409175 @default.
• W2913883970 hasAuthorship W2913883970A5069976865 @default.
• W2913883970 hasAuthorship W2913883970A5089205791 @default.
• W2913883970 hasBestOaLocation W29138839701 @default.
• W2913883970 hasConcept C126838900 @default.
• W2913883970 hasConcept C142724271 @default.
• W2913883970 hasConcept C143409427 @default.
• W2913883970 hasConcept C149550507 @default.
• W2913883970 hasConcept C169760540 @default.
• W2913883970 hasConcept C2776925932 @default.
• W2913883970 hasConcept C2777670902 @default.
• W2913883970 hasConcept C2779134260 @default.
• W2913883970 hasConcept C2781197716 @default.
• W2913883970 hasConcept C3018011982 @default.
• W2913883970 hasConcept C41008148 @default.
• W2913883970 hasConcept C45715564 @default.
• W2913883970 hasConcept C502032728 @default.
• W2913883970 hasConcept C54355233 @default.
• W2913883970 hasConcept C70721500 @default.
• W2913883970 hasConcept C71924100 @default.
• W2913883970 hasConcept C86803240 @default.
• W2913883970 hasConceptScore W2913883970C126838900 @default.
• W2913883970 hasConceptScore W2913883970C142724271 @default.
• W2913883970 hasConceptScore W2913883970C143409427 @default.
• W2913883970 hasConceptScore W2913883970C149550507 @default.
• W2913883970 hasConceptScore W2913883970C169760540 @default.
• W2913883970 hasConceptScore W2913883970C2776925932 @default.
• W2913883970 hasConceptScore W2913883970C2777670902 @default.
• W2913883970 hasConceptScore W2913883970C2779134260 @default.
• W2913883970 hasConceptScore W2913883970C2781197716 @default.
• W2913883970 hasConceptScore W2913883970C3018011982 @default.
• W2913883970 hasConceptScore W2913883970C41008148 @default.
• W2913883970 hasConceptScore W2913883970C45715564 @default.
• W2913883970 hasConceptScore W2913883970C502032728 @default.
• W2913883970 hasConceptScore W2913883970C54355233 @default.
• W2913883970 hasConceptScore W2913883970C70721500 @default.
• W2913883970 hasConceptScore W2913883970C71924100 @default.
• W2913883970 hasConceptScore W2913883970C86803240 @default.
• W2913883970 hasLocation W29138839701 @default.
• W2913883970 hasLocation W29138839702 @default.
• W2913883970 hasLocation W29138839703 @default.
• W2913883970 hasOpenAccess W2913883970 @default.
• W2913883970 hasPrimaryLocation W29138839701 @default.
• W2913883970 hasRelatedWork W1886844647 @default.
• W2913883970 hasRelatedWork W2102136350 @default.
• W2913883970 hasRelatedWork W2146693559 @default.
• W2913883970 hasRelatedWork W2170835722 @default.
• W2913883970 hasRelatedWork W2764192351 @default.
• W2913883970 hasRelatedWork W2794217300 @default.
• W2913883970 hasRelatedWork W2959408566 @default.
• W2913883970 hasRelatedWork W2965213848 @default.
• W2913883970 hasRelatedWork W4308332022 @default.
• W2913883970 hasRelatedWork W4313648027 @default.

• next