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• W2913885785 startingPage "839" @default.
• W2913885785 abstract "Several experimental and clinical studies have shown that dietary nitrate supplementation can increase nitric oxide bioavailability. In the oral cavity, commensal bacteria reduce nitrate to nitrite, which is subsequently absorbed into the circulation where reduction to nitric oxide by enzymatic systems occur. Although it is well-known that boosting the nitrate-nitrite-nitric oxide pathway can improve cardiovascular, renal, and metabolic functions and that sympathoexcitation contributes to the development of the same disorders, the potential effects of dietary nitrate on sympathetic activity remain to be elucidated. In this study, we hypothesized that treatment with inorganic nitrate could prevent the increase in sympathetic nerve activity in an experimental model of Ang II (angiotensin II)-induced hypertension. Multiple in vivo approaches were combined, that is, Wistar rats orally treated with the nitric oxide synthase inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester, 0.5 g/L) and implanted with subcutaneous osmotic minipump for continuous delivery of Ang II (120 ng/kg per minute; 14 days). Simultaneously, rats were supplemented with sodium nitrate (10 mmol/L) or placebo (sodium chloride; 10 mmol/L) in the drinking water. Blood pressure, heart rate, and renal sympathetic nerve activity were recorded. In placebo-treated rats, Ang II+L-NAME treatment-induced arterial hypertension, which was linked with reduced spontaneous baroreflex sensitivity and increased renal sympathetic nerve activity, as well as upregulation of AT1Rs (Ang II type-1 receptors) in the rostral ventrolateral medulla. Supplementation with nitrate normalized the expression of AT1Rs in rostral ventrolateral medulla and reduced sympathetic nerve activity, which was associated with attenuated development of hypertension. In conclusion, chronic dietary nitrate supplementation blunted the development of hypertension via mechanisms that involve reduction of sympathetic outflow." @default.
• W2913885785 created "2019-02-21" @default.
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• W2913885785 date "2019-04-01" @default.
• W2913885785 modified "2023-10-16" @default.
• W2913885785 title "Dietary Nitrate Reduces Blood Pressure in Rats With Angiotensin II–Induced Hypertension via Mechanisms That Involve Reduction of Sympathetic Hyperactivity" @default.
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• W2913885785 cites W1966743313 @default.
• W2913885785 cites W1974569195 @default.
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• W2913885785 cites W1985549269 @default.
• W2913885785 cites W2000087476 @default.
• W2913885785 cites W2001306570 @default.
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• W2913885785 cites W2033357754 @default.
• W2913885785 cites W2033880803 @default.
• W2913885785 cites W2034287553 @default.
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• W2913885785 cites W2038469589 @default.
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• W2913885785 cites W2074218884 @default.
• W2913885785 cites W2100293227 @default.
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• W2913885785 cites W2128632568 @default.
• W2913885785 cites W2133236934 @default.
• W2913885785 cites W2141545453 @default.
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• W2913885785 cites W2163290008 @default.
• W2913885785 cites W2163403433 @default.
• W2913885785 cites W2166467005 @default.
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• W2913885785 cites W2346681063 @default.
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• W2913885785 cites W2461497625 @default.
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• W2913885785 doi "https://doi.org/10.1161/hypertensionaha.118.12425" @default.
• W2913885785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30712424" @default.
• W2913885785 hasPublicationYear "2019" @default.
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