FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913887078> ?p ?o ?g. }

• W2913887078 endingPage "1592" @default.
• W2913887078 startingPage "1583" @default.
• W2913887078 abstract "Chronic inflammation is a hallmark of impaired healing in a plethora of tissues, including skin, and is associated with aging and diseases such as diabetes. Diabetic chronic skin wounds are characterized by excessive myeloid cells that display an aberrant phenotype, partially mediated by stable intrinsic changes induced during hematopoietic development. However, the relative contribution of myeloid cell–intrinsic factors to chronic inflammation versus aberrant signals from the local environmental was unknown. Moreover, identification of myeloid cell intrinsic factors that contribute to chronic inflammation in diabetic wounds remained elusive. Here we show that Gr-1+CD11b+ myeloid cells are retained specifically within the presumptive granulation tissue region of the wound at a higher density in diabetic mice and associate with endothelial cells at the site of injury with a higher frequency than in nondiabetic mice. Adoptive transfer of myeloid cells demonstrated that aberrant wound retention is due to myeloid cell intrinsic factors and not the local environment. RNA sequencing of bone marrow and wound-derived myeloid cells identified Selplg as a myeloid cell intrinsic factor that is deregulated in chronic wounds. In vivo blockade of this protein significantly accelerated wound healing in diabetic mice and may be a potential therapeutic target in chronic wounds and other chronic inflammatory diseases." @default.
• W2913887078 created "2019-02-21" @default.
• W2913887078 creator A5009642712 @default.
• W2913887078 creator A5025623922 @default.
• W2913887078 creator A5041162242 @default.
• W2913887078 creator A5042597116 @default.
• W2913887078 creator A5053091728 @default.
• W2913887078 creator A5073623854 @default.
• W2913887078 creator A5075294396 @default.
• W2913887078 creator A5086775536 @default.
• W2913887078 date "2019-07-01" @default.
• W2913887078 modified "2023-10-16" @default.
• W2913887078 title "Chronic Inflammation in Response to Injury: Retention of Myeloid Cells in Injured Tissue Is Driven by Myeloid Cell Intrinsic Factors" @default.
• W2913887078 cites W1596524641 @default.
• W2913887078 cites W1878538572 @default.
• W2913887078 cites W1920090685 @default.
• W2913887078 cites W1958768935 @default.
• W2913887078 cites W1965434649 @default.
• W2913887078 cites W1969806743 @default.
• W2913887078 cites W1977631233 @default.
• W2913887078 cites W1980735247 @default.
• W2913887078 cites W1984008787 @default.
• W2913887078 cites W2004238073 @default.
• W2913887078 cites W2018877410 @default.
• W2913887078 cites W2020466593 @default.
• W2913887078 cites W2041591721 @default.
• W2913887078 cites W2057864569 @default.
• W2913887078 cites W2068530668 @default.
• W2913887078 cites W2077266466 @default.
• W2913887078 cites W2098846895 @default.
• W2913887078 cites W2103005291 @default.
• W2913887078 cites W2103266497 @default.
• W2913887078 cites W2118654016 @default.
• W2913887078 cites W2120803742 @default.
• W2913887078 cites W2133465414 @default.
• W2913887078 cites W2136356167 @default.
• W2913887078 cites W2147979269 @default.
• W2913887078 cites W2149423081 @default.
• W2913887078 cites W2158217645 @default.
• W2913887078 cites W2164438030 @default.
• W2913887078 cites W2215361131 @default.
• W2913887078 cites W2232019977 @default.
• W2913887078 cites W2329076138 @default.
• W2913887078 cites W2468508424 @default.
• W2913887078 cites W2472373179 @default.
• W2913887078 cites W2534008312 @default.
• W2913887078 cites W2782554903 @default.
• W2913887078 cites W82443941 @default.
• W2913887078 doi "https://doi.org/10.1016/j.jid.2018.12.030" @default.
• W2913887078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30703358" @default.
• W2913887078 hasPublicationYear "2019" @default.
• W2913887078 type Work @default.
• W2913887078 sameAs 2913887078 @default.
• W2913887078 citedByCount "12" @default.
• W2913887078 countsByYear W29138870782019 @default.
• W2913887078 countsByYear W29138870782020 @default.
• W2913887078 countsByYear W29138870782021 @default.
• W2913887078 countsByYear W29138870782022 @default.
• W2913887078 countsByYear W29138870782023 @default.
• W2913887078 crossrefType "journal-article" @default.
• W2913887078 hasAuthorship W2913887078A5009642712 @default.
• W2913887078 hasAuthorship W2913887078A5025623922 @default.
• W2913887078 hasAuthorship W2913887078A5041162242 @default.
• W2913887078 hasAuthorship W2913887078A5042597116 @default.
• W2913887078 hasAuthorship W2913887078A5053091728 @default.
• W2913887078 hasAuthorship W2913887078A5073623854 @default.
• W2913887078 hasAuthorship W2913887078A5075294396 @default.
• W2913887078 hasAuthorship W2913887078A5086775536 @default.
• W2913887078 hasBestOaLocation W29138870781 @default.
• W2913887078 hasConcept C185592680 @default.
• W2913887078 hasConcept C190283241 @default.
• W2913887078 hasConcept C203014093 @default.
• W2913887078 hasConcept C2776914184 @default.
• W2913887078 hasConcept C2779282312 @default.
• W2913887078 hasConcept C2993711000 @default.
• W2913887078 hasConcept C2994430510 @default.
• W2913887078 hasConcept C502942594 @default.
• W2913887078 hasConcept C55493867 @default.
• W2913887078 hasConcept C71924100 @default.
• W2913887078 hasConcept C86803240 @default.
• W2913887078 hasConcept C95444343 @default.
• W2913887078 hasConceptScore W2913887078C185592680 @default.
• W2913887078 hasConceptScore W2913887078C190283241 @default.
• W2913887078 hasConceptScore W2913887078C203014093 @default.
• W2913887078 hasConceptScore W2913887078C2776914184 @default.
• W2913887078 hasConceptScore W2913887078C2779282312 @default.
• W2913887078 hasConceptScore W2913887078C2993711000 @default.
• W2913887078 hasConceptScore W2913887078C2994430510 @default.
• W2913887078 hasConceptScore W2913887078C502942594 @default.
• W2913887078 hasConceptScore W2913887078C55493867 @default.
• W2913887078 hasConceptScore W2913887078C71924100 @default.
• W2913887078 hasConceptScore W2913887078C86803240 @default.
• W2913887078 hasConceptScore W2913887078C95444343 @default.
• W2913887078 hasIssue "7" @default.
• W2913887078 hasLocation W29138870781 @default.
• W2913887078 hasLocation W29138870782 @default.
• W2913887078 hasOpenAccess W2913887078 @default.
• W2913887078 hasPrimaryLocation W29138870781 @default.

• next