Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913903539> ?p ?o ?g. }
- W2913903539 abstract "As targeted personalised therapy becomes more widely used in human medicine, clients will expect the veterinary clinician to be able to implement an evidence-based strategy regarding both the prescribing of medicines and also recognition of the potential for adverse drug reactions (ADR) for their pet, at breed and individual level. This dissertation aims to provide an overview of current developments and challenges in pharmacogenetics in medicine for a veterinary audience and to map these to developments in veterinary pharmacogenetics. Pharmacogenetics has been in development over the past 100 years but has been revolutionised following the publication of the human, and then veterinary species genomes. Genetic biomarkers called pharmacogenes have been identified as specific genetic loci on chromosomes which are associated with either positive or adverse drug responses. Pharmacogene variation may be classified according to the associated drug response, such as a change in (1) the pharmacokinetics; (2) the pharmacodynamics; (3) genes in the downstream pathway of the drug or (4) the effect of “off-target” genes resulting in a response that is unrelated to the intended target. There are many barriers to translation of pharmacogenetic information to the clinic, however, in human medicine, international initiatives are promising real change in the delivery of personalised medicine by 2025. We argue that for effective translation into the veterinary clinic, clinicians, international experts and stakeholders must collaborate to ensure quality assurance and genetic test validation so that animals may also benefit from this genomics revolution." @default.
- W2913903539 created "2019-02-21" @default.
- W2913903539 creator A5056293303 @default.
- W2913903539 creator A5055875510 @default.
- W2913903539 date "2019-02-11" @default.
- W2913903539 modified "2023-10-06" @default.
- W2913903539 title "Translating Pharmacogenetics and Pharmacogenomics to the Clinic: Progress in Human and Veterinary Medicine" @default.
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