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• W2913907520 abstract "Pre‐mRNA splicing is catalyzed by the spliceosome, a multimegadalton RNA–protein complex. The spliceosome undergoes dramatic compositional and conformational changes through the splicing cycle, forming at least 10 distinct complexes. Recent high‐resolution cryoEM structures of various spliceosomal complexes revealed unprecedented details of this large molecular machine. This review highlights insight into the structure and function of the spliceosomal RNA components obtained from these new structures, with a focus on the yeast spliceosome. This article is categorized under: RNA Processing > Splicing Mechanisms RNA Structure and Dynamics > RNA Structure, Dynamics, and Chemistry RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes" @default.
• W2913907520 created "2019-02-21" @default.
• W2913907520 creator A5024096089 @default.
• W2913907520 creator A5041282060 @default.
• W2913907520 creator A5081927192 @default.
• W2913907520 creator A5086485257 @default.
• W2913907520 date "2019-02-06" @default.
• W2913907520 modified "2023-10-15" @default.
• W2913907520 title "RNAs in the spliceosome: Insight from cryoEM structures" @default.
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