Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913909521> ?p ?o ?g. }
- W2913909521 endingPage "337" @default.
- W2913909521 startingPage "325" @default.
- W2913909521 abstract "Alzheimer disease neuropathology is characterized by the extracellular accumulation of Aβ peptide and intracellular aggregation of hyperphosphorylated tau. With the progression of the disease, macroscopic atrophy affects the entorhinal area and hippocampus, amygdala, and associative regions of the neocortex. The locus coeruleus is depigmented. The deposition of Aβ is first made of diffuse deposits. Amyloid focal deposits constitute the core of the senile plaque which also comprises a corona of tau-positive neurites. Aβ deposits are found successively in the neocortex, the hippocampus, the striatum, the mesencephalon, and finally the cerebellum together with the pontine nuclei (Thal phases). Tau pathology affects in a stereotyped order some specific nuclei of the brainstem, the entorhinal area, the hippocampus, and the neocortex – first the associative areas and secondarily the primary cortices (Braak stages). Loss of synapses is observed in association with tau and Aβ pathology; neuronal loss occurs in the most affected areas. Granulovacuolar degeneration and perisomatic granules are also linked to Alzheimer disease pathology. The physiopathology of Alzheimer disease remains unknown. Familial cases suggest that Aβ deposition is the initial step, but tau pathology appears early in the course and seems to be better correlated with the symptoms." @default.
- W2913909521 created "2019-02-21" @default.
- W2913909521 creator A5024292943 @default.
- W2913909521 creator A5039383646 @default.
- W2913909521 date "2018-01-01" @default.
- W2913909521 modified "2023-10-17" @default.
- W2913909521 title "Alzheimer disease" @default.
- W2913909521 cites W1520903105 @default.
- W2913909521 cites W1521432501 @default.
- W2913909521 cites W1558118820 @default.
- W2913909521 cites W1586314603 @default.
- W2913909521 cites W1603244154 @default.
- W2913909521 cites W1605886981 @default.
- W2913909521 cites W1616122655 @default.
- W2913909521 cites W1824128114 @default.
- W2913909521 cites W1884195388 @default.
- W2913909521 cites W1911014954 @default.
- W2913909521 cites W1933780834 @default.
- W2913909521 cites W1963568158 @default.
- W2913909521 cites W1967823816 @default.
- W2913909521 cites W1968324269 @default.
- W2913909521 cites W1969271586 @default.
- W2913909521 cites W1970146034 @default.
- W2913909521 cites W1971032265 @default.
- W2913909521 cites W1973109217 @default.
- W2913909521 cites W1973295647 @default.
- W2913909521 cites W1974560467 @default.
- W2913909521 cites W1976452134 @default.
- W2913909521 cites W1981458288 @default.
- W2913909521 cites W1981923730 @default.
- W2913909521 cites W1986295281 @default.
- W2913909521 cites W1987364373 @default.
- W2913909521 cites W1990179157 @default.
- W2913909521 cites W1990264298 @default.
- W2913909521 cites W1990752558 @default.
- W2913909521 cites W1991435932 @default.
- W2913909521 cites W2003591201 @default.
- W2913909521 cites W2003618511 @default.
- W2913909521 cites W2003776455 @default.
- W2913909521 cites W2006231600 @default.
- W2913909521 cites W2006955217 @default.
- W2913909521 cites W2010357514 @default.
- W2913909521 cites W2010434059 @default.
- W2913909521 cites W2015860144 @default.
- W2913909521 cites W2018254986 @default.
- W2913909521 cites W2020240430 @default.
- W2913909521 cites W2022416480 @default.
- W2913909521 cites W2026970282 @default.
- W2913909521 cites W2027177575 @default.
- W2913909521 cites W2032221178 @default.
- W2913909521 cites W2034378924 @default.
- W2913909521 cites W2036223263 @default.
- W2913909521 cites W2037950411 @default.
- W2913909521 cites W2039379003 @default.
- W2913909521 cites W2039705617 @default.
- W2913909521 cites W2041956586 @default.
- W2913909521 cites W2042151184 @default.
- W2913909521 cites W2044403745 @default.
- W2913909521 cites W2048445940 @default.
- W2913909521 cites W2051218719 @default.
- W2913909521 cites W2051918798 @default.
- W2913909521 cites W2052742260 @default.
- W2913909521 cites W2063272219 @default.
- W2913909521 cites W2064751532 @default.
- W2913909521 cites W2066411218 @default.
- W2913909521 cites W2070137740 @default.
- W2913909521 cites W2072476769 @default.
- W2913909521 cites W2075444764 @default.
- W2913909521 cites W2080225612 @default.
- W2913909521 cites W2081061369 @default.
- W2913909521 cites W2081533023 @default.
- W2913909521 cites W2086552679 @default.
- W2913909521 cites W2087243986 @default.
- W2913909521 cites W2087697089 @default.
- W2913909521 cites W2091444488 @default.
- W2913909521 cites W2093650784 @default.
- W2913909521 cites W2100026237 @default.
- W2913909521 cites W2100610042 @default.
- W2913909521 cites W2103440561 @default.
- W2913909521 cites W2110774263 @default.
- W2913909521 cites W2128228199 @default.
- W2913909521 cites W2129497119 @default.
- W2913909521 cites W2131303491 @default.
- W2913909521 cites W2135496343 @default.
- W2913909521 cites W2138638156 @default.
- W2913909521 cites W21428969 @default.
- W2913909521 cites W2143461767 @default.
- W2913909521 cites W2146729934 @default.
- W2913909521 cites W2149168676 @default.
- W2913909521 cites W2150747374 @default.
- W2913909521 cites W2152580129 @default.
- W2913909521 cites W2163958074 @default.
- W2913909521 cites W2166336042 @default.
- W2913909521 cites W2171259749 @default.
- W2913909521 cites W2172053191 @default.
- W2913909521 cites W2463189234 @default.
- W2913909521 cites W4297738240 @default.
- W2913909521 cites W96835730 @default.