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• W2913909735 abstract "Abstract Objective To determine the effects of varying doses of orally administered BPA on indices of glucose metabolism. Methods Eleven college students (21.0 ± 0.8 years; 24.2 ± 3.9 kg/m2) were randomized in a double-blinded, crossover fashion separated by &gt;1 week to placebo (PL), deuterated BPA at 4 µg/kg body weight (BPA-4), and deuterated BPA at 50 µg/kg body weight (BPA-50). Total BPA, glucose, insulin, and C-peptide were assessed at baseline, minutes 15, 30, 45, 60, and every 30 minutes for 2 hours in response to a glucose tolerance test. Results There was a significant condition × time interaction for total BPA (P &lt; 0.001) such that BPA increased more rapidly in BPA-50 than BPA-4 and PL (P = 0.003) and increased more rapidly in BPA-4 than PL (P &lt; 0.001). There were no significant condition × time interactions on glucose, insulin, and C-peptide. Significant condition main effects were observed for glucose such that BPA-50 was significantly lower than PL (P = 0.036) and nearly lower for BPA-4 vs PL (P = 0.056). Significant condition main effects were observed such that insulin in BPA-50 was lower than BPA-4 (P = 0.021), and C-peptide in BPA-50 was lower than BPA-4 (t18 = 3.95; Tukey-adjusted P = 0.003). Glucose, insulin, and C-peptide areas under the curve for the 3-hour profile were significantly lower in BPA-50 vs PL (P &lt; 0.05). Conclusion Orally administered BPA protocol appeared feasible and has immediate effects on glucose, insulin, and C-peptide concentrations." @default.
• W2913909735 created "2019-02-21" @default.
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• W2913909735 date "2019-02-08" @default.
• W2913909735 modified "2023-10-16" @default.
• W2913909735 title "Pilot Study on the Effect of Orally Administered Bisphenol A on Glucose and Insulin Response in Nonobese Adults" @default.
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• W2913909735 doi "https://doi.org/10.1210/js.2018-00322" @default.
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