Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913953399> ?p ?o ?g. }
- W2913953399 endingPage "3961" @default.
- W2913953399 startingPage "3946" @default.
- W2913953399 abstract "Although VPAC1 and its ligand vasoactive intestinal peptide (VIP) are important in gastrointestinal physiology, their involvements in progression of gastrointestinal tumor have not been explored. Here, we found that higher expression of VIP/VPAC1 was observed in gastric cancer compared to the adjacent normal tissues. The increased expression of VIP/VPAC1 in gastric cancer correlated positively with invasion, tumor stage, lymph node, distant metastases, and poor survival. Moreover, high expression of VIP and VPAC1, advanced tumor stage and distant metastasis were independent prognostic factors. VPAC1 activation by VIP markedly induced TRPV4-mediated Ca2+ entry, and eventually promoted gastric cancer progression in a Ca2+ signaling-dependent manner. Inhibition of VPAC1 and its signaling pathway could block the progressive responses. VPAC1/TRPV4/Ca2+ signaling in turn enhanced the expression and secretion of VIP in gastric cancer cells, enforcing a positive feedback regulation mechanism. Taken together, our study demonstrate that VPAC1 is significantly overexpressed in gastric cancer and VPAC1/TRPV4/Ca2+ signaling axis could enforce a positive feedback regulation in gastric cancer progression. VIP/VPAC1 may serve as potential prognostic markers and therapeutic targets for gastric cancer." @default.
- W2913953399 created "2019-02-21" @default.
- W2913953399 creator A5011922155 @default.
- W2913953399 creator A5043978359 @default.
- W2913953399 creator A5044962091 @default.
- W2913953399 creator A5045567978 @default.
- W2913953399 creator A5052226142 @default.
- W2913953399 creator A5053257075 @default.
- W2913953399 creator A5059933519 @default.
- W2913953399 creator A5074683778 @default.
- W2913953399 creator A5075358581 @default.
- W2913953399 creator A5076006361 @default.
- W2913953399 creator A5077322975 @default.
- W2913953399 date "2019-01-28" @default.
- W2913953399 modified "2023-10-17" @default.
- W2913953399 title "VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism" @default.
- W2913953399 cites W1007539167 @default.
- W2913953399 cites W127904619 @default.
- W2913953399 cites W1485297825 @default.
- W2913953399 cites W1549316628 @default.
- W2913953399 cites W1584311799 @default.
- W2913953399 cites W1889807109 @default.
- W2913953399 cites W1944995278 @default.
- W2913953399 cites W1955052620 @default.
- W2913953399 cites W1965421782 @default.
- W2913953399 cites W1975201674 @default.
- W2913953399 cites W1975426439 @default.
- W2913953399 cites W1977286827 @default.
- W2913953399 cites W1979862805 @default.
- W2913953399 cites W1979903970 @default.
- W2913953399 cites W1984786772 @default.
- W2913953399 cites W1986240989 @default.
- W2913953399 cites W2009164207 @default.
- W2913953399 cites W2011411373 @default.
- W2913953399 cites W2023811422 @default.
- W2913953399 cites W2026909226 @default.
- W2913953399 cites W2028006820 @default.
- W2913953399 cites W2036145275 @default.
- W2913953399 cites W2041740826 @default.
- W2913953399 cites W2052410726 @default.
- W2913953399 cites W2055337042 @default.
- W2913953399 cites W2057315057 @default.
- W2913953399 cites W2059565374 @default.
- W2913953399 cites W2063107254 @default.
- W2913953399 cites W2065397577 @default.
- W2913953399 cites W2071818455 @default.
- W2913953399 cites W2081848364 @default.
- W2913953399 cites W2086722326 @default.
- W2913953399 cites W2101358268 @default.
- W2913953399 cites W2118163294 @default.
- W2913953399 cites W2127686099 @default.
- W2913953399 cites W2128926964 @default.
- W2913953399 cites W2133817684 @default.
- W2913953399 cites W2136738215 @default.
- W2913953399 cites W2139884458 @default.
- W2913953399 cites W2151919855 @default.
- W2913953399 cites W2161146215 @default.
- W2913953399 cites W2172650099 @default.
- W2913953399 cites W2235523093 @default.
- W2913953399 cites W2277686845 @default.
- W2913953399 cites W2429713509 @default.
- W2913953399 cites W2474136078 @default.
- W2913953399 cites W2504137499 @default.
- W2913953399 cites W2537658549 @default.
- W2913953399 cites W2565217910 @default.
- W2913953399 cites W2582158726 @default.
- W2913953399 cites W2757828382 @default.
- W2913953399 cites W4253580260 @default.
- W2913953399 cites W180842620 @default.
- W2913953399 doi "https://doi.org/10.1038/s41388-019-0709-6" @default.
- W2913953399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30692637" @default.
- W2913953399 hasPublicationYear "2019" @default.
- W2913953399 type Work @default.
- W2913953399 sameAs 2913953399 @default.
- W2913953399 citedByCount "30" @default.
- W2913953399 countsByYear W29139533992019 @default.
- W2913953399 countsByYear W29139533992020 @default.
- W2913953399 countsByYear W29139533992021 @default.
- W2913953399 countsByYear W29139533992022 @default.
- W2913953399 countsByYear W29139533992023 @default.
- W2913953399 crossrefType "journal-article" @default.
- W2913953399 hasAuthorship W2913953399A5011922155 @default.
- W2913953399 hasAuthorship W2913953399A5043978359 @default.
- W2913953399 hasAuthorship W2913953399A5044962091 @default.
- W2913953399 hasAuthorship W2913953399A5045567978 @default.
- W2913953399 hasAuthorship W2913953399A5052226142 @default.
- W2913953399 hasAuthorship W2913953399A5053257075 @default.
- W2913953399 hasAuthorship W2913953399A5059933519 @default.
- W2913953399 hasAuthorship W2913953399A5074683778 @default.
- W2913953399 hasAuthorship W2913953399A5075358581 @default.
- W2913953399 hasAuthorship W2913953399A5076006361 @default.
- W2913953399 hasAuthorship W2913953399A5077322975 @default.
- W2913953399 hasBestOaLocation W29139533992 @default.
- W2913953399 hasConcept C118303440 @default.
- W2913953399 hasConcept C121608353 @default.
- W2913953399 hasConcept C126322002 @default.
- W2913953399 hasConcept C128240485 @default.
- W2913953399 hasConcept C134018914 @default.