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- W2913975064 abstract "We hypothesized that an inadequate increase in heart rate (HR) during exercise was associated with low peak oxygen uptake (VO 2 peak) seen in left ventricular assist device (LVAD) recipients and aimed to analyze the potential relation between HR and VO 2 peak and use of drugs with negative chronotropic effect. Sixty-eight LVAD recipients (44 Heartmate 2 and 24 HeartWare Ventricular Assist Device) with support duration >1 month and a VO 2 peak were included from two centers. Patients were 57 ± 13 years at time of VO 2 peak and LVAD support duration was 483 ± 545 days. Peak oxygen uptake was 12 ± 4 ml/kg/min (40% ± 13% of predicted). Heart rate reserve (HRR = maximal HR − resting HR) was 59 ± 22 min − 1 (75% ± 15% of predicted for age, %HRR) and was significantly associated with VO 2 peak (r = 0.244, p = 0.045). Predicted heart rate reserve was associated with %Predicted VO 2 peak ( P = 0.011). Chronotropic incompetence (CI) was observed in 44% and VO 2 peak was clearly lower in patients with CI (10 ± 2.7 vs. 13 ± 4.6 ml/kg/min, p = 0.005). Beta-blockers (BB) were prescribed to 85% and adjusting for being on target BB-dose did not affect the correlation between %predicted VO 2 peak and %HRR (r = 0.33, p = 0.024). In conclusion, almost half of LVAD recipients suffer from CI which is associated with lower VO 2 peak. This relation did not seem to be affected by BB therapy." @default.
- W2913975064 created "2019-02-21" @default.
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- W2913975064 date "2020-02-01" @default.
- W2913975064 modified "2023-10-10" @default.
- W2913975064 title "Effect of Heart Rate Reserve on Exercise Capacity in Patients Treated with a Continuous Left Ventricular Assist Device" @default.
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- W2913975064 doi "https://doi.org/10.1097/mat.0000000000000955" @default.
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