Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913980995> ?p ?o ?g. }
Showing items 1 to 39 of
39
with 100 items per page.
- W2913980995 startingPage "50" @default.
- W2913980995 abstract "锌指蛋白6（ZBED6）基因是新发现的一个转录调控因子，与肌肉的生长发育密切相关，可调控胰岛素样生长因子2（Insulin-like growth factor 2，IGF2）在内的多种基因的表达，为哺乳动物特有，序列高度保守。IGF2作为重要的生长调节因子，内含子3区域可与ZBED6结合，ZBED6的结合可抑制IGF2表达，进而调控细胞的增殖分化和肌肉的生长发育。总结了目前对ZBED6基因的生理功能研究进展，已有研究表明ZBED6可抑制IGF2的表达，促进骨骼肌、心脏、肝脏、肾脏等器官的生长发育，降低脂肪沉积，体内蛋白质、脂质等生物大分子的代谢过程也随之发生变化，ZBED6在糖尿病、癌症的发展过程中均发挥着重要的调控作用。此外，还总结了影响ZBED6表达的多种因素，包括碱基突变、DNA甲基化、组蛋白修饰以及回文序列等。最后，展望了ZBED6的实际应用潜力，其作为一个与肌肉生长发育密切相关的转录因子，可通过敲除ZBED6促进肌肉生长，为瘦肉型动物的遗传育种提供了新的思路。" @default.
- W2913980995 created "2019-02-21" @default.
- W2913980995 creator A5010191880 @default.
- W2913980995 creator A5020984201 @default.
- W2913980995 creator A5037768893 @default.
- W2913980995 creator A5044250932 @default.
- W2913980995 creator A5077376511 @default.
- W2913980995 creator A5077831728 @default.
- W2913980995 creator A5086906464 @default.
- W2913980995 creator A5090402363 @default.
- W2913980995 date "2018-11-26" @default.
- W2913980995 modified "2023-09-28" @default.
- W2913980995 title "锌指蛋白6（ZBED6）研究进展" @default.
- W2913980995 doi "https://doi.org/10.13560/j.cnki.biotech.bull.1985.2018-0449" @default.
- W2913980995 hasPublicationYear "2018" @default.
- W2913980995 type Work @default.
- W2913980995 sameAs 2913980995 @default.
- W2913980995 citedByCount "0" @default.
- W2913980995 crossrefType "journal-article" @default.
- W2913980995 hasAuthorship W2913980995A5010191880 @default.
- W2913980995 hasAuthorship W2913980995A5020984201 @default.
- W2913980995 hasAuthorship W2913980995A5037768893 @default.
- W2913980995 hasAuthorship W2913980995A5044250932 @default.
- W2913980995 hasAuthorship W2913980995A5077376511 @default.
- W2913980995 hasAuthorship W2913980995A5077831728 @default.
- W2913980995 hasAuthorship W2913980995A5086906464 @default.
- W2913980995 hasAuthorship W2913980995A5090402363 @default.
- W2913980995 hasConcept C41008148 @default.
- W2913980995 hasConceptScore W2913980995C41008148 @default.
- W2913980995 hasIssue "11" @default.
- W2913980995 hasLocation W29139809951 @default.
- W2913980995 hasOpenAccess W2913980995 @default.
- W2913980995 hasPrimaryLocation W29139809951 @default.
- W2913980995 hasVolume "34" @default.
- W2913980995 isParatext "false" @default.
- W2913980995 isRetracted "false" @default.
- W2913980995 magId "2913980995" @default.
- W2913980995 workType "article" @default.