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- W2913990480 abstract "Frontal fibrosing alopecia (FFA) is a relatively new scarring alopecia that is considered a variant of lichen planopilaris (LPP) with no recognized promising treatments. In this study, we tried to clarify the underlying signaling pathways and their roles in the pathogenesis and progression of FFA. Because of several differences in clinical manifestations, response to treatments, and pathological findings, these two conditions could be differentiated from each other. Taking into account the already discussed signaling pathways and involved players such as T cells, mast cells, and sebaceous glands, different possible therapeutic options could be suggested. In addition to treatments supported by clinical evidence, such as 5 alpha-reductase inhibitors, topical calcineurin inhibitors, hydroxychloroquine, peroxisome proliferator-activated receptor gamma agonists, and oral retinoid agents, various other treatment strategies and drugs, such as phototherapy, Janus kinase inhibitors, dehydroepiandrosterone, sirolimus, cetirizine, and rituximab, could be suggested to mitigate disease progression. Of course, such lines of treatment need further evaluation in clinical trials." @default.
- W2913990480 created "2019-02-21" @default.
- W2913990480 creator A5014368565 @default.
- W2913990480 creator A5041410495 @default.
- W2913990480 creator A5047775427 @default.
- W2913990480 creator A5049181801 @default.
- W2913990480 creator A5068878485 @default.
- W2913990480 creator A5079316481 @default.
- W2913990480 date "2019-06-01" @default.
- W2913990480 modified "2023-10-16" @default.
- W2913990480 title "Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment" @default.
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- W2913990480 doi "https://doi.org/10.1016/j.ijwd.2018.11.003" @default.
- W2913990480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6451751" @default.
- W2913990480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30997385" @default.
- W2913990480 hasPublicationYear "2019" @default.