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- W2913995660 startingPage "78" @default.
- W2913995660 abstract "Hepatic ischemia-reperfusion injury (IRI), an inevitable event during liver transplantation, represents a major risk factor for the primary graft dysfunction as well as the development of acute and chronic rejection. Neutrophils, along macrophages are pivotal in the innate immune-driven liver IRI, whereas the effective neutrophil targeting therapies remain to be established. In this review, we summarize progress in our appreciation of the neutrophil biology and discuss neutrophil-based therapeutic perspectives.New technological advances enable to accurately track neutrophil movements and help to understand molecular mechanisms in neutrophil function, such as selective recruitment to IR-stressed tissue, formation of neutrophil extracellular traps, or reverse migration into circulation. In addition to pro-inflammatory and tissue-destructive functions, immune regulatory and tissue-repairing phenotype associated with distinct neutrophil subsets, have been identified.Newly recognized and therapeutically attractive neutrophil characteristics warrant comprehensive preclinical and clinical attention to target IRI in transplant recipients." @default.
- W2913995660 created "2019-02-21" @default.
- W2913995660 creator A5016218484 @default.
- W2913995660 creator A5085502935 @default.
- W2913995660 creator A5088101609 @default.
- W2913995660 date "2019-01-29" @default.
- W2913995660 modified "2023-10-18" @default.
- W2913995660 title "The Evolving Role of Neutrophils in Liver Transplant Ischemia-Reperfusion Injury" @default.
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