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• W2914006242 endingPage "e1007603" @default.
• W2914006242 startingPage "e1007603" @default.
• W2914006242 abstract "The variation in weight within a shared environment is largely attributable to genetic factors. Whilst many genes/loci confer susceptibility to obesity, little is known about the genetic architecture of healthy thinness. Here, we characterise the heritability of thinness which we found was comparable to that of severe obesity (h2 = 28.07 vs 32.33% respectively), although with incomplete genetic overlap (r = -0.49, 95% CI [-0.17, -0.82], p = 0.003). In a genome-wide association analysis of thinness (n = 1,471) vs severe obesity (n = 1,456), we identified 10 loci previously associated with obesity, and demonstrate enrichment for established BMI-associated loci (pbinomial = 3.05x10-5). Simulation analyses showed that different association results between the extremes were likely in agreement with additive effects across the BMI distribution, suggesting different effects on thinness and obesity could be due to their different degrees of extremeness. In further analyses, we detected a novel obesity and BMI-associated locus at PKHD1 (rs2784243, obese vs. thin p = 5.99x10-6, obese vs. controls p = 2.13x10-6 pBMI = 2.3x10-13), associations at loci recently discovered with much larger sample sizes (e.g. FAM150B and PRDM6-CEP120), and novel variants driving associations at previously established signals (e.g. rs205262 at the SNRPC/C6orf106 locus and rs112446794 at the PRDM6-CEP120 locus). Our ability to replicate loci found with much larger sample sizes demonstrates the value of clinical extremes and suggest that characterisation of the genetics of thinness may provide a more nuanced understanding of the genetic architecture of body weight regulation and may inform the identification of potential anti-obesity targets." @default.
• W2914006242 created "2019-02-21" @default.
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• W2914006242 date "2019-01-24" @default.
• W2914006242 modified "2023-10-18" @default.
• W2914006242 title "Genetic architecture of human thinness compared to severe obesity" @default.
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• W2914006242 cites W1967814408 @default.
• W2914006242 cites W1976329437 @default.
• W2914006242 cites W1978750038 @default.
• W2914006242 cites W1978823050 @default.
• W2914006242 cites W1983270011 @default.
• W2914006242 cites W1990598085 @default.
• W2914006242 cites W1991704577 @default.
• W2914006242 cites W1992005334 @default.
• W2914006242 cites W1992436001 @default.
• W2914006242 cites W1995227419 @default.
• W2914006242 cites W2003629248 @default.
• W2914006242 cites W2008589990 @default.
• W2914006242 cites W2020172718 @default.
• W2914006242 cites W2020588240 @default.
• W2914006242 cites W2024250377 @default.
• W2914006242 cites W2026884584 @default.
• W2914006242 cites W2033151532 @default.
• W2914006242 cites W2039153962 @default.
• W2914006242 cites W2047783882 @default.
• W2914006242 cites W2049703728 @default.
• W2914006242 cites W2050639176 @default.
• W2914006242 cites W2058496207 @default.
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• W2914006242 cites W2065531094 @default.
• W2914006242 cites W2075690247 @default.
• W2914006242 cites W2076329702 @default.
• W2914006242 cites W2077656178 @default.
• W2914006242 cites W2087193872 @default.
• W2914006242 cites W2099786709 @default.
• W2914006242 cites W2099846538 @default.
• W2914006242 cites W2102213696 @default.
• W2914006242 cites W2114299351 @default.
• W2914006242 cites W2123263006 @default.
• W2914006242 cites W2133517490 @default.
• W2914006242 cites W2133520037 @default.
• W2914006242 cites W2143509157 @default.
• W2914006242 cites W2149200222 @default.
• W2914006242 cites W2149791927 @default.
• W2914006242 cites W2149920649 @default.
• W2914006242 cites W2153860431 @default.
• W2914006242 cites W2157752701 @default.
• W2914006242 cites W2161633633 @default.
• W2914006242 cites W2161998322 @default.
• W2914006242 cites W2164163537 @default.
• W2914006242 cites W2181632153 @default.
• W2914006242 cites W2195783463 @default.
• W2914006242 cites W2199798003 @default.
• W2914006242 cites W2216458865 @default.
• W2914006242 cites W2216513861 @default.
• W2914006242 cites W2269695812 @default.
• W2914006242 cites W2293647101 @default.
• W2914006242 cites W2345621280 @default.
• W2914006242 cites W2346183877 @default.
• W2914006242 cites W2346806116 @default.
• W2914006242 cites W2403857053 @default.
• W2914006242 cites W2488609201 @default.
• W2914006242 cites W2511515754 @default.
• W2914006242 cites W2512007813 @default.
• W2914006242 cites W2605047022 @default.
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• W2914006242 doi "https://doi.org/10.1371/journal.pgen.1007603" @default.
• W2914006242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6345421" @default.
• W2914006242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30677029" @default.
• W2914006242 hasPublicationYear "2019" @default.
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