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• W2914018423 endingPage "113" @default.
• W2914018423 startingPage "102" @default.
• W2914018423 abstract "Exposure to psychosocial stress is known to precipitate the emergence of stress related psychiatric disorders such as depression and anxiety. While mechanisms by which this occurs remain largely unclear, recent evidence points towards a causative role for inflammation. Neurotransmitters, such as norepinephrine (NE), are capable of regulating expression of proinflammatory cytokines and thus may contribute to the emergence of stress-related disorders. The locus coeruleus (LC) is the major source of norepinephrine (NE) to the brain and therefore the current study utilized N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), an LC selective noradrenergic neurotoxin, to determine the discrete involvement of the LC-NE system in social defeat-induced inflammation in LC projection regions including the central amygdala (CeA), dorsal raphe (DR) and plasma. In the current study, rats were exposed to brief social defeat or control manipulations on 5 consecutive days. To determine whether a history of social defeat enhanced or primed the inflammatory response to a subsequent defeat exposure, all rats regardless of stress history were exposed to an acute social defeat challenge immediately preceeding tissue collection. As anticipated, prior history of social defeat primed inflammatory responses in the plasma and CeA while neuroinflammation in the DR was markedly reduced. Notably, DSP-4 treatment suppressed stress-induced circulating inflammatory cytokines independent of prior stress history. In contrast, neuroinflammation in the CeA and DR were greatly augmented selectively in DSP-4 treated rats with a history of social defeat. Together these data highlight the dichotomous nature of NE in stress-induced inflammatory priming in the periphery and the brain and directly implicate the LC-NE system in these processes." @default.
• W2914018423 created "2019-02-21" @default.
• W2914018423 creator A5032887878 @default.
• W2914018423 creator A5035997328 @default.
• W2914018423 creator A5046526288 @default.
• W2914018423 creator A5053103016 @default.
• W2914018423 creator A5057366306 @default.
• W2914018423 creator A5061980676 @default.
• W2914018423 creator A5082887754 @default.
• W2914018423 date "2019-07-01" @default.
• W2914018423 modified "2023-10-17" @default.
• W2914018423 title "The contribution of the locus coeruleus-norepinephrine system in the emergence of defeat-induced inflammatory priming" @default.
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