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- W2914031867 abstract "The S100 protein family has attracted great interest in the field of biomarker research, and a growing number of studies reveal dysregulation of many of the 21 S100 protein isoforms in various human diseases. In cancer, S100 protein expression has been associated with tumor growth, progression, and response to treatment. Some S100 proteins are also considered candidate therapeutic targets. From an analytical perspective, multiplexed analysis of the family-wide S100 protein expression is challenging due to their relatively small size and high-sequence identity. Here we describe a mass spectrometry method using selected reaction monitoring which enables the targeted, multiplexed detection and quantitation of the entire S100 protein family in cell lines and tissue samples." @default.
- W2914031867 created "2019-02-21" @default.
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- W2914031867 date "2019-01-01" @default.
- W2914031867 modified "2023-10-03" @default.
- W2914031867 title "Targeted Mass Spectrometry of S100 Proteins" @default.
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- W2914031867 doi "https://doi.org/10.1007/978-1-4939-9030-6_41" @default.
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