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• W2914045732 abstract "Copper is an important element indispensable for human life and health. Many copper-determining probes have been created for exploring its functional behavior in various cell types but few of them contains both fluorescent and colorimetric characters. In the present study, we developed a set of copper probes by synthesizing several novel thiophene-based Schiff bases in order to make a suitable sensor for quantifying and imaging copper in living cells. We find that the ligand FS-1 has a splendid selectivity and affinity toward Cu2+ among the common divalent metal ions. Living cell imaging show that FS-1 has a robust and repetitive fluorescence response in the presence of Cu2+ only in the cytosolic space of Hepg2 cell and not in the other cells examined. These data suggest that we have developed a new copper probe that can be used as a Cu2+ fluorescent and colorimetric sensor for in vivo and in vitro copper studies." @default.
• W2914045732 created "2019-02-21" @default.
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• W2914045732 date "2019-05-01" @default.
• W2914045732 modified "2023-09-24" @default.
• W2914045732 title "Synthesis and living cell imaging of a novel fluorescent sensor for selective cupric detection" @default.
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• W2914045732 doi "https://doi.org/10.1016/j.saa.2019.02.013" @default.
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