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- W2914047527 abstract "Objective To assess the clinical significance of red blood cell distribution width (RDW), mean platelet volume (MPV), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR) and platelet to lymphocyte ratio (PLR) in predicting cirrhosis in Chinese patients with autoimmune hepatitis (AIH). Methods Peripheral blood cell analysis was conducted in 111 AIH patients to calculate these inflammatory markers based on blood cell count. Binary logistic regression analysis was performed to analyze the risk factors of liver cirrhosis and receiver operating characteristic (ROC) curve was conducted to evaluate the diagnostic value of each index in identifying cirrhosis patients from chronic patients with AIH. Results Serum levels of indicators reflecting liver function including total protein, albumin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were abnormal in patients with AIH, and there was a significant difference between AIH cirrhosis group and chronic AIH group (P<0.05). Inflammatory indices based on blood cell analysis including RDW, MPV and NLR were 15.75%(14.20%-17.60%), (11.75±1.30)f L and 2.60(1.76-3.94) respectively in AIH patients with cirrhosis, elevated remarkably compared to chronic AIH patients. Binary logistic regression analysis showed that RDW and MPV were identified to be independent risk factors of cirrhosis with OR(95%CI) of 1.349(1.128-1.614) and 1.465(1.044-2.056) respectively; ROC analysis showed that the areas under the ROC curve (AUC) of RDW and MPV were 0.736 and 0.675 respectively. Conclusion RDW and MPV were independent risk factors associated with AIH cirrhosis and can serve as reference indices to monitor disease course in AIH.DOI: 10.11855/j.issn.0577-7402.2018.12.08" @default.
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- W2914047527 date "2018-12-01" @default.
- W2914047527 modified "2023-09-27" @default.
- W2914047527 title "Predictive and diagnostic value of red blood cell distribution width and mean platelet volume in autoimmune hepatitis related cirrhosis" @default.
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