FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914057310> ?p ?o ?g. }

• W2914057310 endingPage "872" @default.
• W2914057310 startingPage "861" @default.
• W2914057310 abstract "MiR-138-5p is regarded as a tumour suppressor in many cancers. Transforming growth factor beta (TGF-β) often acts as a tumor promotor at the late stages of human cancers. However, the function of miR-138-5p on lung adenocarcinoma cells induced by TGF-β remains to be further confirmed. RT-qPCR was used to detect the expression of human lung adenocarcinoma tissues, adjacent normal tissues, and relative cell lines. When the lung adenocarcinoma cells A549 and H1299 were transfected with negative control (NC), miR-138-5p mimics and miR-138-5p inhibitor by lipofectamine3000 and treated with or without TGF-β1, the lung adenocarcinoma cell function was detected by Immunofluorescence, Western blotting (WB), cell counting Kit-8 (CCK8), colony formation, EdU, Wound-healing and Transwell assays. The relation between miR-138-5p and zinc finger E-box-binding homeobox 2 (ZEB2) was detected by RT-qPCR, WB, and Luciferase reporter assays. When ZEB2 was knocked down, the lung adenocarcinoma cell function was detected by WB, CCK8 and Transwell assays. The expression of miR-138-5p was decreased in lung adenocarcinoma tissues and cell lines. When treated with or without TGF-β1, overexpression of miR-138-5p suppressed EMT, proliferation and metastasis of A549 and H1299. ZEB2 was verified as the direct target of miR-138-5p. Downregulation of ZEB2 suppressed EMT, proliferation and metastasis of lung adenocarcinoma cell, which could be reversed by miR-138-5p inhibitor. MiR-138-5p inhibits epithelial-mesenchymal transition, growth and metastasis of lung adenocarcinoma cells through targeting ZEB2." @default.
• W2914057310 created "2019-02-21" @default.
• W2914057310 creator A5032316996 @default.
• W2914057310 creator A5040011584 @default.
• W2914057310 creator A5040613734 @default.
• W2914057310 creator A5050601535 @default.
• W2914057310 creator A5058132534 @default.
• W2914057310 creator A5085461586 @default.
• W2914057310 date "2019-05-01" @default.
• W2914057310 modified "2023-09-28" @default.
• W2914057310 title "MiR-138-5p suppresses lung adenocarcinoma cell epithelial-mesenchymal transition, proliferation and metastasis by targeting ZEB2" @default.
• W2914057310 cites W1593805248 @default.
• W2914057310 cites W1912392551 @default.
• W2914057310 cites W1966701340 @default.
• W2914057310 cites W1972750785 @default.
• W2914057310 cites W1984585747 @default.
• W2914057310 cites W1993035383 @default.
• W2914057310 cites W1996892129 @default.
• W2914057310 cites W1998000044 @default.
• W2914057310 cites W2025647419 @default.
• W2914057310 cites W2047670749 @default.
• W2914057310 cites W2052041317 @default.
• W2914057310 cites W2068499430 @default.
• W2914057310 cites W2079332910 @default.
• W2914057310 cites W2118459716 @default.
• W2914057310 cites W2128091264 @default.
• W2914057310 cites W2130211111 @default.
• W2914057310 cites W2140551998 @default.
• W2914057310 cites W2141962249 @default.
• W2914057310 cites W2150881491 @default.
• W2914057310 cites W2153954746 @default.
• W2914057310 cites W2154116432 @default.
• W2914057310 cites W2158374747 @default.
• W2914057310 cites W2169961966 @default.
• W2914057310 cites W2328933401 @default.
• W2914057310 cites W2406320186 @default.
• W2914057310 cites W2408170734 @default.
• W2914057310 cites W2409189950 @default.
• W2914057310 cites W2536901971 @default.
• W2914057310 cites W2588324600 @default.
• W2914057310 cites W2603695819 @default.
• W2914057310 cites W2611455529 @default.
• W2914057310 cites W2734101152 @default.
• W2914057310 cites W2793008236 @default.
• W2914057310 cites W3194141558 @default.
• W2914057310 cites W3195697977 @default.
• W2914057310 doi "https://doi.org/10.1016/j.prp.2019.01.029" @default.
• W2914057310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30712885" @default.
• W2914057310 hasPublicationYear "2019" @default.
• W2914057310 type Work @default.
• W2914057310 sameAs 2914057310 @default.
• W2914057310 citedByCount "36" @default.
• W2914057310 countsByYear W29140573102019 @default.
• W2914057310 countsByYear W29140573102020 @default.
• W2914057310 countsByYear W29140573102021 @default.
• W2914057310 countsByYear W29140573102022 @default.
• W2914057310 countsByYear W29140573102023 @default.
• W2914057310 crossrefType "journal-article" @default.
• W2914057310 hasAuthorship W2914057310A5032316996 @default.
• W2914057310 hasAuthorship W2914057310A5040011584 @default.
• W2914057310 hasAuthorship W2914057310A5040613734 @default.
• W2914057310 hasAuthorship W2914057310A5050601535 @default.
• W2914057310 hasAuthorship W2914057310A5058132534 @default.
• W2914057310 hasAuthorship W2914057310A5085461586 @default.
• W2914057310 hasConcept C121608353 @default.
• W2914057310 hasConcept C137738243 @default.
• W2914057310 hasConcept C142724271 @default.
• W2914057310 hasConcept C1491633281 @default.
• W2914057310 hasConcept C185592680 @default.
• W2914057310 hasConcept C2776256026 @default.
• W2914057310 hasConcept C2779013556 @default.
• W2914057310 hasConcept C2781182431 @default.
• W2914057310 hasConcept C502942594 @default.
• W2914057310 hasConcept C54009773 @default.
• W2914057310 hasConcept C54355233 @default.
• W2914057310 hasConcept C62112901 @default.
• W2914057310 hasConcept C71924100 @default.
• W2914057310 hasConcept C76419328 @default.
• W2914057310 hasConcept C81729549 @default.
• W2914057310 hasConcept C81885089 @default.
• W2914057310 hasConcept C86803240 @default.
• W2914057310 hasConceptScore W2914057310C121608353 @default.
• W2914057310 hasConceptScore W2914057310C137738243 @default.
• W2914057310 hasConceptScore W2914057310C142724271 @default.
• W2914057310 hasConceptScore W2914057310C1491633281 @default.
• W2914057310 hasConceptScore W2914057310C185592680 @default.
• W2914057310 hasConceptScore W2914057310C2776256026 @default.
• W2914057310 hasConceptScore W2914057310C2779013556 @default.
• W2914057310 hasConceptScore W2914057310C2781182431 @default.
• W2914057310 hasConceptScore W2914057310C502942594 @default.
• W2914057310 hasConceptScore W2914057310C54009773 @default.
• W2914057310 hasConceptScore W2914057310C54355233 @default.
• W2914057310 hasConceptScore W2914057310C62112901 @default.
• W2914057310 hasConceptScore W2914057310C71924100 @default.
• W2914057310 hasConceptScore W2914057310C76419328 @default.
• W2914057310 hasConceptScore W2914057310C81729549 @default.
• W2914057310 hasConceptScore W2914057310C81885089 @default.
• W2914057310 hasConceptScore W2914057310C86803240 @default.

• next