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- W2914057812 abstract "The combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for non-invasive investigation of cortical response and connectivity in the human cortex. Single-pulse TMS (spTMS) can probe cortical functions by examining TMS-evoked EEG responses. Few studies have explored the spatiotemporal characteristics of TMS-evoked potentials (TEPs) induced by spTMS in older adults (OLD: >60 yrs) and in patients with schizophrenia (SCZ: 18-59 yrs) compared to healthy young participants (YNG: 18-59 yrs). The aims of this study were to examine the amplitudes and latencies of each TEP component induced by stimulation to the left motor (M1) and dorsolateral prefrontal cortex (DLPFC) in several regions of interest among the YNG, OLD, and SCZ groups. Compared to the YNG group, M1-spTMS induced lower amplitudes of N45 and P180 in the OLD group and a lower amplitude of P180 in the SCZ group, whereas the DLPFC-spTMS induced a lower N45 in the OLD group. Further, the OLD group demonstrated latency delays in P60 after M1-spTMS and in N45-P60 over the right central region after left DLPFC-spTMS, whereas the SCZ group demonstrated latency delays in N45-P60 over the midline central and right central regions after DLPFC spTMS. Together, these findings suggest that inhibitory and excitatory mechanisms mediating TEPs may be altered in older adults and patients with schizophrenia. The amplitude and latency changes of TEPs with spTMS may reflect underlying neurophysiological changes in healthy aging and schizophrenia, respectively. The present findings warrant further study in a larger sample." @default.
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- W2914057812 date "2019-03-01" @default.
- W2914057812 modified "2023-09-23" @default.
- W2914057812 title "Spatiotemporal characteristics of single-pulse TMS-evoked potentials from M1 and DLPFC in healthy participants and patients with schizophrenia" @default.
- W2914057812 doi "https://doi.org/10.1016/j.brs.2018.12.346" @default.
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