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- W2914090508 abstract "Factor XIII (FXIII) has long been recognized for its role as one of the family of transglutaminase enzymes which cross-link proteins and stabilize fibrin clot formation. In the past 5 years, investigators have further expanded our understanding of this important tetramer by demonstrating its specific activity in platelet function, vascular biology, inflammation, and innate immunity. These insights further explain the unique presentation of severe FXIII deficiency, including bleeding pattern and frequency of miscarriage and poor wound healing. New agents to treat FXIII deficiency have become available in the last 5 years as well, and promise to normalize hemostasis and improve outcomes for patients worldwide." @default.
- W2914090508 created "2019-02-21" @default.
- W2914090508 creator A5027842100 @default.
- W2914090508 creator A5072084826 @default.
- W2914090508 date "2014-04-24" @default.
- W2914090508 modified "2023-10-14" @default.
- W2914090508 title "Factor XIII Deficiency" @default.
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- W2914090508 doi "https://doi.org/10.1002/9781118398258.ch59" @default.
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