Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914093001> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2914093001 abstract "ABSTRACT DEF6, also known as SLAT and IBP, is critical for the development of autoimmune disease and cancer. In T cells, DEF6 participates in TCR-mediated signalling determining T helper cell-mediated immune responses. In addition, DEF6 acts as a guanine nucleotide exchange factor for Rho GTPases facilitating F-actin assembly and stabilisation of the immunological synapse. However, DEF6 is also a component of mRNA processing bodies (P-bodies) linking it to mRNA metabolism. DEF6 can adopt multiple conformations that result in different cellular localisations and functions. Post translational modifications such as phosphorylation result in conformational change liberating functional domains that are masked in the native stage of DEF6. ITK phosphorylation of Try210/222 liberates the N-terminal end and to a certain extend also the C-terminal coiled coil domain of DEF6 resulting in P-body colocalisation. In fact, the N-terminal 45 amino acids of DEF6 that encode a Ca2+-binding EF hand are sufficient to target P-bodies. Mutant proteins that unleashed the C-terminal coiled coil domain of DEF6 spontaneously aggregated forming large vesicle-like, cytoplasmic structures. These aggregates trapped proteins such as the P-body component DCP1 altering its cytoplasmic localisation. However, cellular stress reversed aggregate formation in mutant DEF6 proteins that contained ITAM and PH domain in conjunction with the coiled coil domain resulting in colocalisation with DCP1. Furthermore, coiled coil-mediated aggregates appeared to function like prions enforcing conformational change onto wild type DEF6 protein." @default.
- W2914093001 created "2019-02-21" @default.
- W2914093001 creator A5034696585 @default.
- W2914093001 creator A5073386796 @default.
- W2914093001 date "2019-02-01" @default.
- W2914093001 modified "2023-09-23" @default.
- W2914093001 title "The coiled coil domain of DEF6 facilitates formation of large vesicle-like, cytoplasmic aggregates that trap the P-body marker DCP1 and exhibit prion-like features" @default.
- W2914093001 cites W1965231243 @default.
- W2914093001 cites W1975464080 @default.
- W2914093001 cites W1976840413 @default.
- W2914093001 cites W1980725044 @default.
- W2914093001 cites W1981638187 @default.
- W2914093001 cites W1985106044 @default.
- W2914093001 cites W1995864250 @default.
- W2914093001 cites W2003911773 @default.
- W2914093001 cites W2004166886 @default.
- W2914093001 cites W2017959781 @default.
- W2914093001 cites W2035385534 @default.
- W2914093001 cites W2042244889 @default.
- W2914093001 cites W2078613655 @default.
- W2914093001 cites W2079570562 @default.
- W2914093001 cites W2097055595 @default.
- W2914093001 cites W2098811095 @default.
- W2914093001 cites W2108663777 @default.
- W2914093001 cites W2112523914 @default.
- W2914093001 cites W2147997023 @default.
- W2914093001 cites W2172219847 @default.
- W2914093001 cites W2520345180 @default.
- W2914093001 cites W2556440865 @default.
- W2914093001 cites W2735831942 @default.
- W2914093001 cites W2911229518 @default.
- W2914093001 doi "https://doi.org/10.1101/538082" @default.
- W2914093001 hasPublicationYear "2019" @default.
- W2914093001 type Work @default.
- W2914093001 sameAs 2914093001 @default.
- W2914093001 citedByCount "0" @default.
- W2914093001 crossrefType "posted-content" @default.
- W2914093001 hasAuthorship W2914093001A5034696585 @default.
- W2914093001 hasAuthorship W2914093001A5073386796 @default.
- W2914093001 hasBestOaLocation W29140930011 @default.
- W2914093001 hasConcept C104317684 @default.
- W2914093001 hasConcept C11960822 @default.
- W2914093001 hasConcept C126619667 @default.
- W2914093001 hasConcept C143065580 @default.
- W2914093001 hasConcept C185592680 @default.
- W2914093001 hasConcept C190062978 @default.
- W2914093001 hasConcept C207332259 @default.
- W2914093001 hasConcept C55493867 @default.
- W2914093001 hasConcept C55988834 @default.
- W2914093001 hasConcept C86803240 @default.
- W2914093001 hasConcept C95444343 @default.
- W2914093001 hasConceptScore W2914093001C104317684 @default.
- W2914093001 hasConceptScore W2914093001C11960822 @default.
- W2914093001 hasConceptScore W2914093001C126619667 @default.
- W2914093001 hasConceptScore W2914093001C143065580 @default.
- W2914093001 hasConceptScore W2914093001C185592680 @default.
- W2914093001 hasConceptScore W2914093001C190062978 @default.
- W2914093001 hasConceptScore W2914093001C207332259 @default.
- W2914093001 hasConceptScore W2914093001C55493867 @default.
- W2914093001 hasConceptScore W2914093001C55988834 @default.
- W2914093001 hasConceptScore W2914093001C86803240 @default.
- W2914093001 hasConceptScore W2914093001C95444343 @default.
- W2914093001 hasLocation W29140930011 @default.
- W2914093001 hasOpenAccess W2914093001 @default.
- W2914093001 hasPrimaryLocation W29140930011 @default.
- W2914093001 hasRelatedWork W2050961829 @default.
- W2914093001 hasRelatedWork W2082028011 @default.
- W2914093001 hasRelatedWork W2089809507 @default.
- W2914093001 hasRelatedWork W2091587849 @default.
- W2914093001 hasRelatedWork W2114673876 @default.
- W2914093001 hasRelatedWork W2145573546 @default.
- W2914093001 hasRelatedWork W2145985400 @default.
- W2914093001 hasRelatedWork W2147095766 @default.
- W2914093001 hasRelatedWork W2810741294 @default.
- W2914093001 hasRelatedWork W3183320474 @default.
- W2914093001 isParatext "false" @default.
- W2914093001 isRetracted "false" @default.
- W2914093001 magId "2914093001" @default.
- W2914093001 workType "article" @default.